| Effects of Portulaca Oleracea on Insulin Resistance in Rats with Type 2 Diabetes Mellitus |
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| 作者姓名： | Shen Lan Lu Fu-er |
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| 作者单位： | Institute of Integrated Traditional & Western Medicine，Tongji Hospital，Tongji Medical College，Huazhong University of Science & Technology，Institute of Integrated Traditional & Western Medicine，Tongji Hospital，Tongji Medical College，Huazhong University of Science & Technology Wuhan (430030)，Wuhan (430030) |
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| 基金项目： | Financially supported by Education Ministry of China (Gr ant No. 1998-679) |
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| 摘 要： | Insulinresistance(IR)isthecommon patho physiologicalbasisforagroupofmetabolicabnormali tiescalledinsulinresistancesyndrome,whichin cludestype 2diabetesmellitus(T2DM),obesity,lipidmetabolicdisturbance,primaryhypertensionandatherosclerosis.ItwasoncereportedthataChinesemedicinalherb,Portulacaoleracea,usedalonecouldeffectivelytreatdiabetesmellitusinhumans(1) asithastheactionofamelioratinghyperlipidemia,andpreventingandcuringatherosclerosis(2,3).Butexper imentalstudyofPortulacaoleraceaoninsulinr…
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| 收稿时间： | 4 November 2002 |
Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus |
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| Authors: | Shen Lan and Lu Fu-er |
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| Abstract: | Objective: To study the effects of Portulaca oler acea, a Chinese medicinal herb, on insulin resistance in rats with type 2 diabet es mellitus (T2DM). Methods: Experimental model of T2DM was established by injection of streptozotocin (25mg/kg) and feeding with high calorie forage. The effects o f Portulaca oleracea on oral glucose tolerance, serum levels of insulin, triglyc eride, total cholesterol, high density lipoproteins cholesterol and free f atty acids, and insulin sensitivity index were all observed. Results: Portulaca oleracea could reduce the body weight, improve the impaired glucose tolerance and lipid metabolism, decrease serum free fatty acids, attenuate hyperinsulinemia and elevate insulin sensitivity. Conclusion: Portulaca oleracea could improve insulin resistance i n rats with T2DM, and the mechanism might be related to its actions in improving lipid metabolism and decreasing free fatty acids. |
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| Keywords: | diabetes mellitus type 2 Portulaca olera cea insulin resistance lipid metabolism free fatty acid |
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