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| 霉酚酸对白蛋白刺激肾小管上皮细胞表达趋化因子的影响 | |
| 引用本文： | 水华,高苹,司晓芸,於文丽,王群. 霉酚酸对白蛋白刺激肾小管上皮细胞表达趋化因子的影响[J]. 武汉大学学报(医学版), 2008, 29(6): 740-742 |
| 作者姓名： | 水华 高苹 司晓芸 於文丽 王群 |
| 作者单位： | 武汉大学中南医院肾内科,湖北武汉,430071;武汉大学中南医院肾内科,湖北武汉,430071;武汉大学中南医院肾内科,湖北武汉,430071;武汉大学中南医院肾内科,湖北武汉,430071;武汉大学中南医院肾内科,湖北武汉,430071 |
| 摘 要： | 目的:探讨霉酚酸对白蛋白刺激肾小管上皮细胞趋化因子RANTES表达的影响。方法:培养大鼠肾小管上皮细胞(NRK-52E),分别加入白蛋白或/和霉酚酸。应用RT-PCR方法测定RANTES mRNA表达,应用Western blot测定RANTES蛋白的表达。结果:白蛋白呈时间依赖性上调肾小管上皮细胞RANTES mRNA和蛋白表达增加。霉酚酸可抑制肾小管上皮细胞RANTES的表达。结论:霉酚酸可抑制白蛋白引起的肾小管上皮细胞分泌RANTES而发挥其抗炎作用。 |
| 关 键 词： | 霉酚酸 RANTES 肾小管上皮细胞 |
Effects of Mycophenolic Acid on the Expression of Chemokines of Tubular Cells Induced by Albumin in Vitro |
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| SHUI Hua,GAO Ping,SI Xiaoyun,YU Wenli,WANG Qun. Effects of Mycophenolic Acid on the Expression of Chemokines of Tubular Cells Induced by Albumin in Vitro[J]. Medical Journal of Wuhan University, 2008, 29(6): 740-742 | |
| Authors: | SHUI Hua GAO Ping SI Xiaoyun YU Wenli WANG Qun |
| Affiliation: | SHUI Hua,GAO Ping,SI Xiaoyun,YU Wenli,WANG QunDept.of Nephrology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China |
| Abstract: | Objective: To investigate the effect of mycophenolic acid(MPA) on the expression of chemokines RANTES in renal tubular epithelial cells stimulated by albumin.Methods: The renal tubular epithelial NRK-52E cells were incubated in the presence of albumin(30 g/L) with or without MPA.Expression of mRNA was analyzed by RT-PCR.Expression of protein RANTES was assessed by Western blot.Results: Albumin stimulated expression of RANTES mRNA and protein in a time-dependent manner.MPA inhibited albumin-induced the expression of RANTES.Conclusion: MPA may inhibit the expression of RANTES in renal tubular epithelial cells. |
| Keywords: | RANTES |
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