Determinants of Repeat Curative Intent Surgery in Colorectal Liver Metastasis |
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| Authors: | Afif N. Kulaylat Neil H. Bhayani Audrey L. Stokes Jane R. Schubart Joyce Wong Eric T. Kimchi Kevin F. Staveley-O’Carroll Jussuf T. Kaifi Niraj J. Gusani |
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| Affiliation: | 1. Program for Liver, Pancreas, and Foregut Tumors, Department of Surgery, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033-0850, USA
2. Department of Public Health Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033-0850, USA
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| Abstract: | ![]()
Introduction Following curative intent surgery (CIS) for colorectal liver metastasis (CRLM), repeat CIS for recurrence improves survival. The factors associated with repeat CIS are not widely reported. Methods An institutional database (January 2002–December 2012) was reviewed to evaluate factors influencing repeat CIS. Results One hundred sixty-three patients with colorectal liver metastasis (CRLM) underwent successful CIS. Median follow-up and disease-free interval (DFI) was 33 and 16 months, respectively. After initial CIS, 102 patients (63 %) recurred. Fifty-three patients (52 %) underwent a repeat CIS. After repeat CIS, 33 patients (62 %) developed a second recurrence, and in 13 patients (39 %), a third CIS was possible. DFI decreased following initial CIS (first CIS vs. second CIS vs. third CIS [20 vs. 15 vs. 8.5 months], p?Conclusion Despite high recurrence and decreasing DFI, repeat CIS provides a survival benefit. Postoperative complications, DFI, number, and pattern of recurrence influence the decision to pursue repeat CIS. |
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