Cardiomyopathy in Soman and Sarin intoxicated rats |
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| Authors: | A W Singer N K Jaax J S Graham C G McLeod |
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| Affiliation: | 1. Comparative Pathology Branch, United States Army Medical Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5425 U.S.A.;1. Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4 W7, Canada;2. Department of Medicine, Peter Munk Cardiac Centre, University Health Network, University of Toronto, GW 3-558A, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada;3. Division of Cardiology, London Health Sciences Centre, 339 Windermere Road, c6-110, London, Ontario N6A 5A5, Canada;4. Division of Cardiology, Department of Medicine, University of British Columbia, 211 1033, Davie Street, Vancouver, British Columbia V6E 1M7, Canada;1. Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA;2. Department of Neurosurgery, Rochester Regional Health, Rochester, New York, USA;1. Department of Biochemistry, Changzhi Medical College, Changzhi, Shanxi 046000, China;2. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China;3. DNA Laboratory, Changzhi Public Security Bureau, Changzhi, Shanxi 046000, China;1. Experimental Toxicology Laboratory, Departamento de Ciências do Mar, Universidade Federal de São Paulo – UNIFESP, Santos, SP, Brazil;2. Núcleo de Estudos em Poluição e Ecotoxicologia Aquática, Campus do Litoral Paulista, Universidade Estadual Paulista – UNESP, São Vicente, SP, Brazil;3. Departamento de Ciências do Mar, Universidade Federal de São Paulo – UNIFESP, Santos, SP, Brazil |
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| Abstract: | ![]()
Rats surviving various single dose of the organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication: half of all animals that had brain lesions also had areas of myocardial degeneration and necrosis. Depending upon the point in time at which cardiac tissues were examined, findings varied from areas of acute myolysis and necrosis to areas undergoing resolution of damage. The finding of brain lesions in those animals having cardiac lesions suggests a relationship between the convulsion induced neurologic and cardiac lesions. These studies suggest that convulsive doses of chemical warfare agents induce pathological changes in the cardiovascular system of laboratory animals. |
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