真武汤合桃红四物汤对阳虚血瘀型慢性收缩性心力衰竭患者血浆 BNP 的影响

目的：观察真武汤合桃红四物汤对阳虚血瘀型慢性心力衰竭（CHF）患者血浆 B 型钠尿肽（BNP）水平的影响。方法80例阳虚血瘀型 CHF 患者入院后测定血浆 BNP 水平，后随机分为对照组40例，联合组40例，对照组西药常规治疗，联合组在西药常规治疗基础上服用真武汤合桃红四物汤，治疗8周后分别观察其疗效、左室射血分数变化及血浆 BNP 水平的变化。结果治疗前患者血浆 BNP 水平分别为：对照组（544.97±213.26）pg / mL，联合组（545.46±211.19）pg / mL，组间比较差异无统计学意义；治疗前患者左室射血分数分别为：对照组44.58％±5.66％，联合组43.38％±6.61％，组间比较差异无统计学意义；对照组、联合组心功能总有效率分别为76.92％、94.87％，联合组优于对照组（P ＜0.05）；治疗后2组血浆 BNP 水平明显下降，差异有统计学意义（P ＜0.01），组间比较差异亦有统计学意义（P ＜0.05）；治疗后2组左室射血分数明显下降，差异有统计学意义（P ＜0.05），但组间比较无统计学意义。结论真武汤合桃红四物汤能改善阳虚血瘀型慢性收缩性心力衰竭患者症状、体征，增加左室射血分数，降低血浆 BNP 水平。

Zhenwu Decoction and Taohongsiwu Decoction on yang deficiency and blood stasis of blood BNp in patients with chronic congestive heart failure

objective To observe effect of Zhenwu Decoction and Taohongsiwu Decoction on Yang deficiency and blood stasis of average BNP in patients with chronic congestive heart failure. Methods The 80 patients with yang de-ficiency and blood stasis type of heart failure were selected to test the average BNP,they were randomly divided into the study group and the control group with 40 cases in each. The control group was treated with routine western medi-cine,the study group was treated with Zhenwu Decoction and Taohongsiwu Decoction on the basis of the control group. The two groups took 8 weeks of continuous treatment. The patients’informations,included curative effect,left ventricular ejection fraction(LVEF),brain natriuretic peptide(BNP),had been collected and observed before and after treatment. Results Before the treatment,the average BNP of the control group was(544. 97 ± 213. 26)pg /mL,the average BNP of the study group was(545. 46 ± 211. 19)pg / mL. There was no difference of the average BNP level in the comparison between the two groups(P > 0. 05). Before the treatment,the LVEF of the control group was 44. 58% ± 5. 66% ,the LVEF of the the study group was 43. 38% ± 6. 61% . There was no difference of the LVEF in the comparison between the two groups(P > 0. 05). The Cardiac function in total effective rate of the control group and the study group were 76. 92% ,94. 87% ,the study group showed the better efficacy than the con-trol group(P < 0. 05). This study showed that the average BNP of the two groups of patients decreased after treat-ment,with significant differences( P < 0. 01). On improving of the decreased level of BNP,the treatment group showed the better efficacy than the control group(P < 0. 05). This study showed that LVEF of the two groups of pa-tients increased after treatment,with significant differences(P < 0. 05);But there was no difference of the increased level of LVEF in the comparison between the two groups . Conclusion Zhenwu Decoction and Taohongsiwu Decoc-tion can improve the clinical symptoms and signs of patients of chronic congestive heart failure with Yang deficiency and blood stasis,and can increase the LVEF,decrease the average BNP.