妊娠期肝内胆汁淤积症与围生儿预后关系的探讨

目的探讨妊娠期肝内胆汁淤积症（ICP）与围生儿预后的关系。方法回顾性分析91例ICP患者与对照组91例正常妊娠孕妇妊娠结局、新生儿体重、胎儿生长受限发生率的比较及新生儿体重与肝功能指标的关系。结果ICP组胎儿窘迫、羊水粪染、早产儿、新生儿窒息、围生儿死亡发生率与对照组比较差异有统计学意义（P〈0.01）。新生儿体重、低体重儿发生率无明显改变，两者比较差异无统计学意义（P〉0.05）。结论ICP影响围生儿预后。

Relationship between the intrahepatic cholestosis of pregnancy and the prognosis of neonates retardation

Objective: To study the relationship between the intrahepatic cholestosis of pregnancy(ICP)and the prognosis of neonates.Methods: A retrospetive method was applied in the analysis of the result of pregnancy,the weight of new-born,the fetal growth in 91 patients with ICP with another 91 normal pregnant women used as the controls to demonstrate the relationship between the weight of new-born and nepatic function paramenters.Results: The occurrence of fetal distress,meconium in amnion,preterm birth,neonatal asphyxia and neonatal death rate were highter in the ICP group than those in the controls(P<0.01).The incidence of low birth weight infant,the weight of new-born had no statistical difference between the two groups(P>0.05).Conclusion: The intrahepatic cholestasis of pregnancy affects prognosis of neonates.