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Analysis of T-cell repertoire and mixed chimaerism in a patient with aplastic anaemia after allogeneic bone marrow transplantation |
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| Authors: | Tsutsumi Yutaka Tanaka Junji Sugita Junichi Kato Naoko Zhang Li Yonezumi Masakatsu Chiba Kouji Toyosima Nobuyasu Kondo Takeshi Ohta Shuichi Mori Akio Hasino Satoshi Asaka Masahiro Imamura Masahiro |
| Affiliation: | Department ofHaematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. |
| Abstract: | We analysed 26 T-cell receptor (TCR) beta chain subfamilies (VB) of a patient with aplastic anaemia (AA) who underwent allogeneic bone marrow transplantation (allo-BMT). The patient developed pancytopenia at d 80. The patient's T cells were skewed in 10 of 26 TCR-VB on d 83. These TCR-VB, especially VB15, which were almost entirely CD8-positive cells, were skewed throughout her clinical course. Chimaerism analysis of the CD8-positive cells indicated that they were of recipient origin. Therefore, some immune responses induced by the recipient CD8-positive T cells had an important role in pancytopenia in AA patients after allo-BMT. |
| Keywords: | bone marrow transplantation (BMT) T-cell repertoire β chain subfamily (TCR-VB) aplastic anaemia (AA) graft rejection chimaerism |
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