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Sex differences in prefrontal volume with aging and Alzheimer's disease |
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| Authors: | Salat D H Stangl P A Kaye J A Janowsky J S |
| Institution: | a Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201–3098, USA b Department of Neurology, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201–3098, USA c Portland Veterans Affairs Medical Center, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201–3098, USA |
| Abstract: | We used volumetric magnetic resonance imaging to examine sex differences in prefrontal tissue volumes of healthy aged and patients with Alzheimer’s disease (AD). Healthy subjects had greater total prefrontal volume than AD, and men had greater total prefrontal volume than women (ps ≤ 0.02). This was true for both gray and white matter volumes. There were no interactions between group and sex for total prefrontal volume. An exploratory analysis of each group suggested that sex differences in both gray and white matter in healthy aging are not sustained in AD. |
| Keywords: | Frontal lobe Prefrontal Sex characteristics Aging Aged Alzheimer’s disease Magnetic resonance imaging Gray matter Human |
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