Prefrontal hyperactivation during a working memory task in early-onset schizophrenia spectrum disorders: An fMRI study |
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| Authors: | Rune Thormodsen,Jimmy Jensen,Aina Holmè n,Monica Juuhl-Langseth,Kyrre Eeg Emblem,Ole Andreas Andreassen,Bjø rn Rishovd Rund |
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| Affiliation: | aVestre Viken Hospital Trust, 1309 Rud, Oslo, Norway;bDepartment of Psychology, University of Oslo, Norway;cDepartment of Psychiatry, Oslo University Hospital, Norway;dInstitute of Psychiatry, University of Oslo, Norway;eAkershus University Hospital, Mental Health Division, Norway;fResearch unit Sogn, Oslo University Hospital, Norway;gThe Interventional Centre, Rikshospitalet, Oslo University Hospital, Norway;hDepartment of Medical Physics, Rikshospitalet, Oslo University Hospital, Norway;iDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germany |
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| Abstract: | Working memory (WM) dysfunction is increasingly recognized as a core feature of schizophrenia, but few studies have investigated prefrontal activation during WM tasks in early-onset schizophrenia spectrum disorder (EOS). Our aim was to explore prefrontal activation during a WM-task in EOS patients compared to healthy controls using functional magnetic resonance imaging (fMRI). Fifteen patients with EOS and 15 matched healthy controls performed a 0-back and a 2-back task while fMRI data were acquired. Results indicated that even though performance between patients and controls was comparable on both tasks, there was a hyperactivation in patients' ventrolateral prefrontal cortex (VLPFC) during the 2-back task compared to healthy controls. This pattern of activation suggests that, in patients with EOS, the VLPFC compensated in order to match performance of the controls. The activations in the EOS group may reflect the use of a compensatory, cognitive strategy while solving WM-tasks. |
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| Keywords: | Ventrolateral prefrontal cortex Maintenance 2-back 0-back n-back |
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