消化道小细胞癌的综合治疗及预后分析

目的　探讨消化道小细胞癌的综合治疗和预后因素。方法　对从 1980年 1月至 1999年 12月收治的 5 2例消化道小细胞癌进行了回顾性分析。结果　全组病人 1年、2年、5年生存率分别为 5 0 %、2 5 %和 11.5 % ,中位生存期为 12个月。其中局限期病人 1年、2年、5年生存率分别为 5 4 %、30 .3%和18.2 % ,中位生存期为 14 .5个月 ;广泛期病人 1年、2年、5年生存率分别为 4 2 .1%、15 .8%和 0 % ,中位生存期为 8个月。结果显示临床分期和治疗手段对长期生存率有显著意义 (P <0 .0 5 )。结论　临床分期和治疗手段是消化道小细胞癌的重要预后因素 ,以化疗为主的综合治疗可以改善患者生存率。

Systemic treatment and prognostic analysis for patients with small cell cancer of the digestive tract

Objective To evaluate the systemic treatment and prognostic factors in the patients with small cell cancer of the digestive tract.Methods From Jan 1980 to Dec, 1999,the 52 patients with the small cell cancer of digestive tract were analysized retrospectively.Results In all the patients 1,2 and 5-year survival rates were 50.0%, 25.0% and 11.5% respectively, the median survival time (MST) was 12 months. In the limited stage (LS) group, the survival rates were 54.5% for 1 year, 30.0% for 2 year and 18.2% for 5 year, MST was 14.5 months. In the extensive stage (ES)group , the survival rates were 42.1% for 1 year, 15.8% for 2 year, zero for 5 year, MST was 8 months. The results showed that the major significant prognostic factors were the clinical stage and the clinical therapeutic methods (P< 0.05).Conclusion The clinical stage and the therapeutic methods are the most important prognostic factors for small cell cancer of digestive tract. Systemic treatment including chemotherapy is very important to improve the survival rate of the patients.