肥胖高血压病患者瘦素水平与代谢紊乱的关系

目的探讨肥胖高血压病患者血清、脂肪组织中瘦素水平与肥胖、高血压、血脂紊乱、胰岛素抵抗等代谢紊乱的关系。方法选取腹部手术患者48例为研究对象，肥胖高血压痛患者（肥胖高血压组）及单纯肥胖患者（单纯肥胖组）各24例，测定血压、体质指数、腰围臀围、血脂、空腹血糖、空腹胰岛素以及血清和大网膜脂肪组织瘦素水平。结果肥胖高血压组患者的血清瘦素、甘油三酯、空腹胰岛素、空腹血糖均显著高于单纯肥胖组（P〈0．01），血清胰岛素敏感指数、高密度脂蛋白显著低于单纯肥胖组（P〈0．01）。肥胖高血压组患者大网膜脂肪组织瘦素水平与单纯肥胖组无统计学意义（P〉0．05）。血清瘦素与性别、体质指数、腰臀比、收缩压和舒张压、空腹胰岛素、空腹血糖呈显著正相关。脂肪组织瘦素水平与上述指标均无统计学意义（P〉0．05）。结论血清瘦素水平与肥胖程度、血压、胰岛素抵抗存在相关性；脂肪组织瘦素水平与血清瘦素水平、肥胖高血压患者的代谢紊乱无明显关联。

Correlation between leptin levels and metablism disorder in hypertensive obesities

Objective To investigate the relationship among serum fat leptin levels, obesity, hypertension, disorder of fat metabolism and insulin resistance in hypertensive obesities. Methods forty - eight patients receiving abdominal operations were included. 24 cases of them suffered from hypertensive obesities, other 24 cases were simple obesity. The indexes of blood pressure, body mass index （ BMI）, waist hip ratio （ WHR）, serum lipid, blood sugar （BS）, insulin （INS）, and serum and fat leptin levels were measured. Results Serum leptin, triglycerides, insulin, and blood glucose in hypertensive obesities group were higher than simple obesity group （ P 〈 0.01）. However, serum insulin sensitivity index （ISI）, high density lipoprotein were lower in hypertensive obesities group （ P 〈 0.01 ）. There was no significant difference of leptin level in omental adipose tissue between two groups （P 〉 0. 05 ）. There was significant positive correlation between serum leptin and sexual distinction, BMI, WHR, SBP, DBP, FINS, FBS. However, there were no significant correlation between leptin level in fat tissue and those indexes above （P 〉 0, 05）. Conehmion Serum leptin levels were related with obesity, blood pressure, insulin resistance. There were no significant relationship between fat leption level and serum leption level, metabolism disorder in hypertensive obesities.