数字连接试验检测肝病患者亚临床肝性脑病的研究

目的 以数字连接试验(NCT)检测慢性肝病尤其是病毒性肝炎患者的亚临床肝性脑病(SHE)发病率，以了解肝功能与SHE的关系。方法 对177例慢性肝病进行NCT检测。结果 慢性肝病患者的NCT异常率31．1％(55／177)，病毒性肝炎患者的NCT异常率29．7％(47／158)；肝功损害轻度及重症肝炎时，肝硬化组与非肝硬化组的NCT异常率无差别，肝功损害中度和重度时，肝硬化组的异常率高于非肝硬化组，且有显著性差异；肝功分级间的SHE发病率无差异；男女间的NCT异常率无差别。结论肝病病人出现智力障碍与肝功损害及肝硬化的门体分流都有关，而与病因无关；肝功损害程度与SHE的发生率末显示线性关系。

The study to examine the subclinical hepatic encephalopathy in hepatic disease patients with number connection test

Objective To examine the subclinical hepatic encephalopathy(SHE) in patients of hepatic disease, especially viral hepatitis, with number connection test(NCT), to comprehend relation between liver function and the subclinical hepatic encephalopathy. Methods 177 patients with liver disease were detected with NCT. Results The abnormal rate of NCT in patients of hepatic disease was 31.1 % (55/177) , in patients of viral hepatitis was 29.7% (47/158) . When the degree of liver function was light and severe hepatitis, the abnormal rate of NCT in cirrhosis patients group and no-cirrhosis patients group hadn' t a significant difference, but it had a significant difference when the degree of liver function was middle and heavy, the abnormal rate of NCT in cirrhosis patients group was higher than no-cirrhosis patients group. The abnormal rate of NCT hadn' t a significant difference between every degree of liver function. And it hadn' t a significant difference between male and female. Conclusions The patients in liver disease appearing intelligence obstruction are assoiated with liver function damage and cirrhosis, it isn' t assoiated with the cause of disease. The degree of liver function damage and the incidence rate of SHE hasn' t linear corelation.