| 短暂局灶预缺血对脑梗死大鼠脑肝细胞生长因子表达的影响 |
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| 引用本文： | 杜业亮,王纪佐,冯进波. 短暂局灶预缺血对脑梗死大鼠脑肝细胞生长因子表达的影响[J]. 脑与神经疾病杂志, 2004, 12(5): 333-334,341 |
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| 作者姓名： | 杜业亮 王纪佐 冯进波 |
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| 作者单位： | 300211,天津,天津医科大学第二医院内科;山东大学齐鲁医院基础研究所 |
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| 摘 要： | 目的:探讨短暂局灶缺血预处理对脑梗死大鼠脑肝细胞生长因子(HGF)表达的影响及其意义。方法:采取线栓法建立局灶脑缺血模型,预处理组大鼠经10分钟短暂预缺血处理.24h后二次处理造成大脑中动脉闭塞,脑梗死组只在第二次处理造成大脑中动脉闭塞。单纯短暂缺血组只在第一次处理时缺血10分钟。各组均在末次处理24小时后用RT-PCR法检测HGF的表达。结果:单纯短暂预缺血组脑缺血边缘区几乎无HGF的表达.预处理组脑梗死边缘区HGF的表达较单纯脑梗死组HGF的表达增强。结论:短暂局灶缺血预处理引起脑梗死边缘区HGF的高表达可能与缺血耐受的产生有一定的关系,对脑缺血损伤组织的保护及修复可能有重要意义。
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| 关 键 词： | Ischemic preconditioning Cerebral infarction Hepatocyte growth factor |
| 文章编号： | 1006-351X(2004)05-0333-02 |
Transient focal ischemic preconditioning increases hepatocyte growth factorexpression in rat brain after regional cerebral infarction |
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| DU Yeliang,WANG Jizuo. FENG Jinbo. Transient focal ischemic preconditioning increases hepatocyte growth factorexpression in rat brain after regional cerebral infarction[J]. Journal of Brain and Nervous Diseases, 2004, 12(5): 333-334,341 |
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| Authors: | DU Yeliang WANG Jizuo. FENG Jinbo |
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| Affiliation: | DU Yeliang,WANG Jizuo. FENG Jinbo Department of Neurology . The second hospital of Tianjin Medical University,Tianjin,300211. China |
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| Abstract: | Objective: To study the changes of hepatocyte growth factor( HGF) expression in rat brain after the middle cerebral occlusion (MCAO) following the ischemic preconditioning (PC). Methods: According to the improved Longa's procedures, the thread was inserted twice. 10 min MCAO was used for transient focal ischemic preconditioning. The second MCAO. which was made at 24h after PC, lasted for another 24h. Expressing of HGF in the ischemic penumbra region was determined by RT-PCR. Results: Compared with MCAO groups. MCAO following PC groups remarkably expressed HGF. Conclusions: The high HGF expression of ischemic penumbra region following PC might associate with the protection mechanism of ischemic tolerance. |
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| Keywords: | Ischemic preconditioning Cerebral infarction Hepatocvle growth factor |
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