| 姜黄素对5种非白念珠菌菌丝及生物膜形成的抑制作用 |
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| 引用本文： | 张梦翔,施高翔,严园园,陆克乔,邵菁,汪天明,汪长中.姜黄素对5种非白念珠菌菌丝及生物膜形成的抑制作用[J].中草药,2015,46(4):549-553. |
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| 作者姓名： | 张梦翔 施高翔 严园园 陆克乔 邵菁 汪天明 汪长中 |
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| 作者单位： | 安徽中医药大学中西医结合临床学院, 安徽 合肥 230038;安徽省中医药科学院中西医结合研究所, 安徽 合肥 230038;安徽中医药大学中西医结合临床学院, 安徽 合肥 230038;安徽省中医药科学院中西医结合研究所, 安徽 合肥 230038;安徽中医药大学中西医结合临床学院, 安徽 合肥 230038;安徽省中医药科学院中西医结合研究所, 安徽 合肥 230038;安徽中医药大学中西医结合临床学院, 安徽 合肥 230038;安徽省中医药科学院中西医结合研究所, 安徽 合肥 230038;安徽中医药大学中西医结合临床学院, 安徽 合肥 230038;安徽省中医药科学院中西医结合研究所, 安徽 合肥 230038;安徽中医药大学中西医结合临床学院, 安徽 合肥 230038;安徽省中医药科学院中西医结合研究所, 安徽 合肥 230038;安徽中医药大学中西医结合临床学院, 安徽 合肥 230038;安徽省中医药科学院中西医结合研究所, 安徽 合肥 230038 |
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| 基金项目： | 国家自然科学基金资助项目(81073127);安徽省自然科学基金项目(1408085MH165);安徽中医药大学校级科研项目(2014zr026) |
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| 摘 要： | 目的观察姜黄素对5种非白念珠菌菌丝及生物膜形成的抑制作用。方法测定姜黄素对热带念珠菌Candidatropicalis、光滑念珠菌C.glabrata、近平滑念珠菌C.parapsilokis、克柔念珠菌C.Krusei、季也蒙念珠菌C.guilliermondii的最小抑菌浓度(MIC)以及抑制50%生物膜浓度(SMIC50),利用光学显微镜观察姜黄素对非白念珠菌菌落形态的影响,利用倒置显微镜与扫描电镜分别观察姜黄素对非白念珠菌菌丝形成以及生物膜形成的影响。结果姜黄素对热带念珠菌、光滑念珠菌、近平滑念珠菌、克柔念珠菌、季也蒙念珠菌的MIC分别为64、128、256、256、128μg/m L;SMIC50分别为512、512、512、512、512μg/m L;倒置显微镜与扫描电镜观察发现姜黄素对5种非白念珠菌菌丝以及生物膜的形成均有抑制作用。光学显微镜观察发现姜黄素能抑制这5种非白念株菌在固体培养基上菌落周边菌丝的形成。结论姜黄素对5种非白念珠菌菌丝及生物膜的形成具有抑制作用。
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| 关 键 词： | 姜黄素 非白念珠菌 菌丝 生物膜 热带念珠菌 光滑念珠菌 近平滑念珠菌 克柔念珠菌 季也蒙念珠菌 |
| 收稿时间： | 2014/10/6 0:00:00 |
Inhibitory effects of curcumin on hyphal development and biofilm formation of five kinds of non-Candida albicans |
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| ZHANG Meng-xiang,SHI Gao-xiang,YAN Yuan-yuan,LU Ke-qiao,SHAO Jing,WANG Tian-ming and WANG Chang-zhong.Inhibitory effects of curcumin on hyphal development and biofilm formation of five kinds of non-Candida albicans[J].Chinese Traditional and Herbal Drugs,2015,46(4):549-553. |
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| Authors: | ZHANG Meng-xiang SHI Gao-xiang YAN Yuan-yuan LU Ke-qiao SHAO Jing WANG Tian-ming and WANG Chang-zhong |
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| Institution: | School of Integrated Traditional Chinese and Western Medicine in Clinic, Anhui University of Chinese Medicine, Hefei 230038, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230038, China;School of Integrated Traditional Chinese and Western Medicine in Clinic, Anhui University of Chinese Medicine, Hefei 230038, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230038, China;School of Integrated Traditional Chinese and Western Medicine in Clinic, Anhui University of Chinese Medicine, Hefei 230038, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230038, China;School of Integrated Traditional Chinese and Western Medicine in Clinic, Anhui University of Chinese Medicine, Hefei 230038, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230038, China;School of Integrated Traditional Chinese and Western Medicine in Clinic, Anhui University of Chinese Medicine, Hefei 230038, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230038, China;School of Integrated Traditional Chinese and Western Medicine in Clinic, Anhui University of Chinese Medicine, Hefei 230038, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230038, China;School of Integrated Traditional Chinese and Western Medicine in Clinic, Anhui University of Chinese Medicine, Hefei 230038, China;Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230038, China |
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| Abstract: | |
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| Keywords: | curcumin non-Candida albicans hyphae biofilms Candida tropicalis Candida glabrata Candida parapsilokis Candida krusei Candida guilliermondii |
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