ITP患者骨髓及血液检测指标与疗效关系的探讨

目的：为观察血小板表面相关抗体Ｇ（ＰａＩｇＧ）、外周血血小板计数（ＢＰＣ）、平均血小板容积（ＭＰＶ）、骨髓巨核细胞计数（ＭＫ）与产板型巨核细胞比例（ＰＰＭＫ）对特发性血小板减少性紫癜（ｉｄｉｏｐａｔｈｉｃ ｔｈｒｏｍｂｏｃｙｔｏｐｅｎｉｃｐｕｒｐｕｒａ，ＩＴＰ）患者疗效的预计价值。方法：采用Ｃｏｕｌｔｅｒ全自动血球分析仪及双抗体夹心ＥＬＩＳＡ法等，对７３例ＩＴＰ患者治疗前和治疗后的ＢＰＣ、ＭＰＶ、

STUDY ON THE VALUES OF EXAMINED INDEXES OF PERIPHERAL BLOOD AND BONE MARROW TO PREDICTION OF THERAPEUTIC EFFECTIVENESS IN PATIENTS WITH ITP

Objective:To investigate the values of peripheral blood BPC,MPV and PaIgG,bone marrow MK count and platelet-producing megakaryocyte(PPMK) rate to the prediction of therapeutic effectiveness in patients with ITP.Methods:73 Cases of ITP were included in this study.Coulter automatic blood cell analyzer was employed to measure the levels of BPC and MPV before and after treatments.PaIgG levels were tested by Sandwich ELISA with double antibodies.Results:BPC level and PPMK rate were lower in ITP group than those in normal control group( P<0.01 ).BPC was negatively correlated to MPV in normal control group( P<0.01 ).In the cases which demonstrated responses to steroid,the response time had no significant correlations to BPC,MPV of pre-treatment,MK count and PaIgG,while had negative correlations to MPV of pro-treatment and PPMK rate of pre-treatment.Conclusion:PPMK rate of pre-treatment and MPV of pro-treatment were related to the response time and therapeutic effectiveness of steroid.They would be considered as reference indexes for the prediction of therapeutic effectiveness in ITP patients.