Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
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| Authors: | Magda O Seixas Larissa C Rocha Mauricio B Carvalho Joelma F Menezes Isa M Lyra Valma ML Nascimento Ricardo D Couto Ájax M Atta Mitermayer G Reis Marilda S Goncalves |
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| Affiliation: | 1.Laboratório de Patologia e Biologia Molecular, Centro de Pesquisa Gon?alo Moniz,Funda??o de Pesquisa Oswaldo Cruz (FIOCRUZ),Salvador,Brasil;2.Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia,Universidade Federal da Bahia,Salvador,Bahia,Brasil;3.Funda??o de Hematologia e Hemoterapia do Estado da Bahia (HEMOBA),Salvador,Brasil;4.Hospital Pediátrico Professor Hosannah de Oliveira,Universidade Federal da Bahia,Salvador,Brasil |
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| Abstract: | Background The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steady-state children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, anti-aggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis. |
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