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| 7一氯苄基四氢巴马汀对大鼠α肾上腺素受体及心电图的影响 | |
| 引用本文： | 曾维忠,姚伟星,夏国瑾,戴水平,江明性,黄文龙,黄忱亚,彭司勋. 7一氯苄基四氢巴马汀对大鼠α肾上腺素受体及心电图的影响[J]. 中国药理学与毒理学杂志, 1995, 0(3) |
| 作者姓名： | 曾维忠 姚伟星 夏国瑾 戴水平 江明性 黄文龙 黄忱亚 彭司勋 |
| 作者单位： | 同济医科大学药理学教研室，中国药科大学药物化学研究室 |
| 摘 要： | 在大鼠肛尾肌标本，７－氯苄基四氢巴马汀（７－ｃｈｌｏｒ－ＢＴＨＰ）１０μｍｏｌ·Ｌ－１能竞争性地抑制苯福林致肛尾肌收缩的量效曲线，使量效曲线右移，最大效应不变，其ｐＡ２值为５．９，但对可乐定抑制电场刺激所致的大鼠输精管收缩的量效曲线无影。在毁脊髓大鼠，７－ｃｈｌｏｒ－ＢＴＨＰ５ｍｇ·ｋｇ－１在不同刺激频率下可使心率减慢，但对电刺激所致的血压升高无影响。７－ｃｈｌｏｒ－ＢＴＨＰ恒速灌注，能剂量依赖性地延长心电图Ｐ－Ｒ间期及减慢心率，直至动物死亡也未见过速性心律失常发生。 |
| 关 键 词： | 抗心律失常药；小檗因类；7－氯苄基四氢巴马汀；受体，肾上腺素能，α；心率 |
Effect of 7-chlor-benzyltetrahydropalmatin onα-adrenoceptors and electrocardiogram in rats |
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| ZENG Wei-Zhong, YAO Wei-Xing, XIA Guo-Jin, DAI Shui-Ping, JIANGMing-Xing, HUANG Wen-Long, HUANG Zhenya, PENG Si-Xun. Effect of 7-chlor-benzyltetrahydropalmatin onα-adrenoceptors and electrocardiogram in rats[J]. Chinese Journal of Pharmacology and Toxicology, 1995, 0(3) | |
| Authors: | ZENG Wei-Zhong YAO Wei-Xing XIA Guo-Jin DAI Shui-Ping JIANGMing-Xing HUANG Wen-Long HUANG Zhenya PENG Si-Xun |
| Abstract: | The contractile response tophenylephrine was competitively inhibited by 10μmol·L-1 7-chlor-benzyltetrahydropalmatine(7-chlor-BTHP) in rat anococcygeus musele, andthe pA2 value was 5.9. Clonidine inhibited the electri-cal stimulation-evoked contraction of the prostaticportion of vas deferens in rat, but 7-chlor-BTHP 10μmol·L-1 was unable to shift the clonidine dose-re-sponse curve indicating that it had no influence onα2-adrenoceptor. In pithed rat, the increase of heartrate evoked with electrical stimulation of spinal seg-ment (T10-12) was attenuated by 5 mg· kg-17-chlor-BTHP, but the pressor response was notaffected. The result of electrocardiogram of the an-esthetized rat indicated that constant infusion of0.5% (85 μL · min-1) 7-chlor-BTHP could obviouslyprolong P-R interval and decrease the heart rate,but tachyarrhythmia did not occur until the death ofthe rat. |
| Keywords: | anti-arrhythmia agents berbines 7-chlor-benzyltetrahydropalmatine receptors,adrenergic, α heart rateThis project was supported by the National NaturalScience Foundation of China, No 30370795 |
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