高血糖高渗状态对老年糖尿病患者甲状腺功能及炎性指标的影响

目的：探讨高血糖高渗状态对老年糖尿病患者甲状腺功能及炎性指标的影响。方法选择2012年1月-2014年1月在我院接受治疗的老年糖尿病高血糖高渗状态患者43例作为观察组，另选同期我院体检的老年糖尿病患者30例为对照组。观察两组血糖、糖化血红蛋白（ HbA1c）和血浆渗透压，甲状腺功能及血浆炎性指标。结果观察组空腹血糖、HbA1c和血浆渗透压均显著高于对照组（P 〈0.01）。观察组血浆三碘甲状腺原氨酸（T3）水平显著低于对照组，血浆 C反应蛋白（CRP）和肿瘤坏死因子α（TNF-α）水平显著高于对照组（P 〈0.01）。观察组血浆 T3水平与 CRP和 TNF-α水平呈现显著负相关（r=-0.743，r=-0.583，P〈0.01）。结论高血糖高渗状态可抑制老年糖尿病患者的甲状腺功能，可能是同时存在的全身性炎性反应所致。

Effect of Hyperglycemic Hyperosmolar Status on Thyroid Function and Inflammation Index in Elderly Patients with Diabetes

Objective To explore the effect of hyperglycemic hyperosmolar status on thyroid function and inflam-mation index in elderly patients with diabetes. Methods A total of 43 elderly diabetic patients with hyperglycemic hy-perosmolar status undergoing treatment during January 2012 and January 2014 was chosen as observation group,and 30 elderly diabetic patients taking medical examinations at the same time were chosen as control group. The values of fasting plasma glucose（FPG）,glycosylated hemoglobin（HbA1c）,plasmic osmotic pressure,thyroid function and inflammation index in the two groups were observed. Results The values of FPG,HbA1c and plasmic osmotic pressure in observation group were significantly higher than those in control group（P〈0. 01）. In observation group,the triiodothyronine（T3） level was significantly lower,while the levels of C-reactive protein（ CRP）and tumor necrosis factor-α（ TNF-α）were significantly higher than those in control group（P〈0. 01）. The T3 level had significantly negative correlation with the levels of CRP and tumor necrosis factorα（TNF-α）in observation group（r= -0. 743,r= -0. 583,P〈0. 01）. Con-clusion Elderly diabetic patients with hyperglycemic hyperosmolar status may inhibit the level of thyroid function,and systemic inflammatory reaction may be found at the same time.