硫普罗宁治疗慢性病毒性肝炎的临床疗效对照研究

目的:评价硫普罗宁治疗慢性病毒性肝炎的临床疗效。方法:将108例慢性病毒性肝炎患者随机分为A,B,C 3组,每组36例。分别接受4周的硫普罗宁针、还原型谷胱甘肽针、基础护肝(葡醛酸钠、肌苷)针治疗,检测患者治疗前后肝功能,临床症状和体征的改善情况。结果:A组改善肝功能及临床症状的总有效率(86.1%)明显优于B组(75.0%,P<0.01)和C组三组(61.1%,P<0.01)。A与B组肝功能ALT和ALB的改善差异无显著性(P>0.05),但对降低AST及TB IL方面A组优于B组(P<0.05)。结论:硫普罗宁能有效地改善肝功能及临床症状。

Clinical efficacy of tiopronin on chronic viral hepatitis

Objective:To evaluate the therapeutic effect of tiopronion on chronic viral hepatitis.Methods:Totally 108 patients with chronic viral hepatitis were randomly divided into three groups(n=36 for each group),and treated for 4 weeks with tiopronion,reduced gluthion and basic liver-protecting drugs(including glucurone and inosine),respectively.Liver function,clinical sings and symptoms were determined in all the patients at the onset and end of the treatments.Results:The overall effective rate of tiopronion(86.1%) to improve liver function and clinical symptom was markedly higher than that of reduced gluthion(75.0%,P<0.01) or basic drugs(61.1%,P<0.01).The effect of tiopronion was similar to that of reduced gluthion on decreasing ALT and ALB(P>0.05),but was superior to that of reduced gluthion on decreasing AST and TBIL(P<0.05).Conclusion:Tiopronion can effectively improve hepatic function and clinical signs of patients with chronic viral hepatitis.