| 伴有抑郁症状急性冠脉综合征早期应用氟哌噻吨美利曲辛疗效观察 |
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| 引用本文： | 王兆宏,陈还珍,闫建玲.伴有抑郁症状急性冠脉综合征早期应用氟哌噻吨美利曲辛疗效观察[J].中华老年多器官疾病杂志,2011,10(3):252-255. |
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| 作者姓名： | 王兆宏 陈还珍 闫建玲 |
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| 作者单位： | 1. 山西省中西医结合医院心内科,太原,030013
2. 山西医科大学第一医院心内科,太原,030001 |
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| 摘 要： | 目的探讨药物干预对伴有抑郁症状的急性冠脉综合征（ACS）患者的临床疗效。方法将入选的94例合并抑郁ACS患者随机分为干预组（n=48）和对照组（n=46）。干预组在冠心病常规治疗上给予氟哌噻吨美利曲辛。两组治疗前后HAMD评分、临床症状和超敏C反应蛋白（hs-CRP）进行比较。结果干预组治疗后HAMD评分明显低于对照组（13±7）vs（26±7）,P〈0.05]。干预组治疗后临床症状改善率明显优于对照组（P〈0.05）。干预组治疗在观察中期和结束时hs-CRP水平下降优于对照组6周时（12.7±4.7）vs（21.3±5.3）mg/L;12周时（8.2±2.2）vs（17.5±4.4）mg/L,P〈0.05]。结论对合并抑郁的ACS患者早期使用氟哌噻吨美利曲辛不仅可以改善抑郁症状,并有助于提早改善冠心病临床症状,降低hs-CRP水平,对ACS患者早期康复及近期预后有重要意义。
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| 关 键 词： | 冠状动脉疾病 抑郁 氟哌噻吨美利曲辛 C反应蛋白 |
Therapeutic effects of flupentixol and melitracen tablets on acute coronary syndrome with depression |
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| WANG Zhaohong,CHEN Huanzhen.Therapeutic effects of flupentixol and melitracen tablets on acute coronary syndrome with depression[J].Chinrse journal of Multiple Organ Diseases in the Elderly,2011,10(3):252-255. |
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| Authors: | WANG Zhaohong CHEN Huanzhen |
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| Institution: | WANG Zhaohong~(1*),CHEN Huanzhen~2,YAN Jianling~1 (1 Department of Cardiology,Shanxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Taiyuan 030013,China,2 Department of Cardiology,First Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | Objective To investigate the effect of drug intervention on acute coronary syndrome(ACS) patients complicated with depression.Methods Ninety-four ACS patients with depression were randomly divided into intervention group(n=48) and control group(n=46).The patients in intervention group were given anti-psychotropic drug,tlupentixol and melitracen tablets,besides routine therapy,while the patients in control group were give routine therapy only.The Hamilton Depression Rating Scale(HAMD),clinical symptoms and l... |
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| Keywords: | acute coronary syndrome depression flupentixol and melitracen hs-CRP |
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