氨溴索对老年慢性阻塞性肺疾病患者开胸术后肺部并发症的预防作用

目的 评估氨溴索对老年慢性阻塞性肺疾病(COPD)患者开胸术后肺部并发症的预防作用.方法 纳入COPD开胸手术后患者(≥70岁)161例,分为两组,氨溴索组在围手术期间静脉应用氨溴索300 mg/d,连用6 d；对照组应用安慰剂.依据临床症状、影像学改变及血气分析诊断肺部并发症.结果 肺不张的发生率氨溴索组8.6％,安慰剂组达28.8％,差异有统计学意义(P＜0.05),与术前相比,氨溴索组术后血氧分压( PaO2)下降较安慰剂组明显(P＜0.05).所有患者未出现药物不良反应.结论 氨溴索可作为老年COPD患者预防开胸术后肺部并发症的药物.

Prevention of bronchopulmonary complications by ambroxol after thoracotomy in patients with chronic obstructive pulmonary disease

Objective To evaluate the effects of ambroxol on prevention of bronchopulmonary complications after thoracotomy in patients with chronic obstructive pulmonary disease(COPD).Methods Total 161 elderly patients aged ≥70 years with COPD undergoing thoracotomy were randomly allocated to two groups:ambroxol group (300 mg/d,6 d) and placebo group as control.Pulmonary complications were evaluated by clinical symptoms,radiographic changes,and blood gas analysis. Results The incidence rates of atelectasis were 8.6％ in ambroxol group and 28.8％ in placebo group,respectively.The PaO2 values after surgery in ambroxol group decreased more than in placebo group (P＜0.05) compared with the preoperative values.Side effects were not found in all patients.Conclusions Ambroxol should be considered as an alternative pharmacologic approach for the prevention of post-thoracotomy pulmonary complications in the elderly patients with COPD.