丙型肝炎病毒感染主要危险因素的Meta分析

目的 分析丙型肝炎病毒(HCV)感染的危险因素。方法计算机检索中国医院知识仓库(CHKD)、万方数据知识平台、EBSCO、西文生物医学期刊文献服务系统、Elsevier,并结合文献追溯的方法,收集1994-2010年公开发表的关于HCV感染危险因素的文献,研究类型为病例对照研究或队列研究,采用RevMan 5.0及St...

Primary risk factors of hepatitis C virus infection: a Meta-analysis

Objective To provide evidence for decision-making on primary hepatitis C prevention through analyzing the main risk factors of hepatitis C virus infection. Methods A comprehensive search was carried out in China Hospital Knowledge Database (CHKD), Wanfang Data, EBSCO, FMJS and Elsevier databases to identify all case-control and cohort studies published from 1994 to 2010 that evaluated the risk factors on the transmission of hepatitis C virus. Data manipulation and statistical analyses were performed using Stata 11.0 and RevMan 5.0 softwares.Results A total of 25 case-control studies were included in this Meta-analysis, which contained 4370 cases and 8606 controls. In univariate analysis, the pooled odds ratio (OR) and 95％ confidence interval (CI) on the risk factors associated with HCV seropositivity were "blood transfusion" 4.23 (2.82-6.35) , "having had surgical operations" 2.13 (1.70-2.67) , "intravenous drug use" 52.28(34.12-80.11 ), "having sex with intravenous drug users" 7.19 ( 3.13- 16.51 ), "histories of having had STDs" 3.43 (2.70-4.34). In multivariate analysis, pooled OR and 95％CI of the risk factors associated with HCV seropositivity were: having had following "histories as blood transfusion" 6.03 (3.97-9.15), "surgeries" 2.10( 1.44-3.07), "intravenous drug use" 44.90(31.13-64.76), "having sex with intravenous drug users" 3.87(2.07-7.24), "having STDs" 2.05(1.19-3.52). Conclusion Blood transfusion、 intravenous drug use and having sex with intravenous drug users were the risk factors of HCV infection. Due to existing biases, the relationship between having had surgical operations and HCV infection was inconclusive. There appeared weak correlation between STDs and HCV infection,but the result was not so stability.