肝受体显象剂~（99m）Tc－DTPA－NGA的研制

报道了肝受体显象剂￣（９９ｍ）Ｔｃ－ＤＴＰＡ－ＮＧＡ的制备方法及其特性研究。该显象剂放化纯度＞９５％，在体外和人体血液中的稳定性均大于６小时，有良好的趋肝性和受体介导结合特性。￣（９９ｍ）Ｔｃ－ＤＴＰＡ－ＮＧＡ和￣（９９ｍ）Ｔｃ－ＮＧＡ对比研究表明，前者在体外和人血液中的稳定性均比后者好；家免显象结果前者质量明显高于后者；尿中放射性代谢产物检测，前者在体内无脱落￣（９９ｍ）Ｔｃ的现象，而后者较明显。临床１０例肝受体显象结果满意。

The Preparation of Hepatic Receptor Imaging Agent~(99m)Tc-DTPA-NGA

The method of preparation and thecharacter of the hepatic receptor imaging agent99mTc-DTPA-NGA have been presented. The radio-chemical purity of the imaging agent is higher than95% and the stability of the imaging agent is morethan 6 hours in vitro and in human blood. The agent isable to tend to liver and has the character of receptor-intervene-conduct binding. Our comparative study of99mTc-DTPA-NGA versus 99mTc-NGA reveals,thestability of the former in vitro and in human blood isbetter than that of the latter. The imaging in rabbitsshows that the imaging quality of the former is higherthan that of the latter.The radioactive metabolite inurine have been examined. The former does not falloff 99mTc in vivo, but the latter falls off 99mTc clear-ly. 10 clinical hepatic imagings have had satisfactoryresults.