瑞巴派特治疗慢性糜烂性胃炎疗效观察

目的观察瑞巴派特治疗慢性糜烂性胃炎的疗效。方法将75例慢性糜烂性胃炎患者随机分成两组：试验组45例,口服瑞巴派特,0.1g/次,3次/d;对照组30例,口服硫糖铝,1.0g/次,3次/d。均治疗8周。治疗前及治疗1、2、4、6、8周对患者上腹痛、上腹胀、反酸和嗳气症状进行症状评分,治疗前、后分别行胃镜检查及胃黏膜组织病理学检查,并进行胃镜下疗效评分和胃黏膜慢性炎症程度、炎症活动程度评分。结果治疗后两组患者上腹痛、上腹胀、反酸和嗳气总积分间差别有统计学意义（P〈0.05）;胃镜评分间比较,差别有显著性意义（P〈0.05）;胃黏膜糜烂区慢性炎症程度及炎症活动程度评分间差别无统计学意义（P〉0.05）。结论瑞巴派特可改善慢性糜烂性胃炎患者的上腹痛、上腹胀、反酸和嗳气等上消化道症状。

Investigation in Therapeutic Effect of Rebamipide on Chronic Erosive Gastritis

Objective To investigate the therapeutic effect of Rebamipide on chronic erosive gastritis.Methods 75 patients with chronic erosive gastritis were randomly divided into 2 groups.45 cases in the treatment group were given Rebamipide orally,0.1 g each time,3 times a day.30 cases in the control group were given Sucralfate orally,1.0 g each time,3 times a day.Both groups were treated for 8 successive weeks.The symptoms of upper abdominal pain,epigastric distention,sour regurgitation,and belching were assessed before and 1,2,4,6,8 weeks after the treatment.Gastroscopic and gastric mucosal histopathologic examination was applied before and after the treatment,then the therapeutic effect of the treatment and the chronic inflammatory activity as well as its severity of the gastric mucosa were assessedResults The general integral calculus difference was significant as for the symptoms of upper abdominal pain,epigastric distention,sour regurgitation,and belching after the treatment(P<0.05).There was significant difference in gastroscopic scoring(P<0.05).The scores of chronic inflammatory activity and its severity of the erosive gastric mucosa were not statistically significant.Conclusion Rebamipide is effective for relieving upper gastrointestinal symptoms of upper abdominal pain,epigastric distention,sour regurgitation,and belching in chronic erosive gastritis patients.