EBV associated lymphomas in 2008 WHO classification |
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| Authors: | Tiantian Zhang Qianqian Fu Dalin Gao Liyan Ge Lin Sun Qiongli Zhai |
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| Affiliation: | 1. Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China;2. Sino-American Diagnostic and Therapeutic Center for Hematological Malignancies, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China;3. Department of Pathology, General Hospital of Tianjin, Dagang, Oilfield, China |
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| Abstract: | Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that asymptomatically infects more than 90% of the world's population. The exact mechanism of EBV in oncogenesis is an area of active debate. However, EBV has been implicated in the pathogenesis of several kinds of lymphomas and lymphoproliferative disorders, including B-, T- and NK-cell derived. Subsequent studies have proven that the EBV gene expression product plays an activating and/or promoting role on lymphomagenesis, and paves the way for novel cellular therapies of EBV-associated lymphomas. This review concentrates on the pathology, morphology, treatment and prognosis of EBV-associated lymphomas in the 2008 WHO classification of tumors of hematopoietic and lymphoma tissues. |
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| Keywords: | Epstein-Barr virus Hodgkin lymphoma B-cell lymphomas NK/T cell lymphomas |
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