肠易激综合征患者服用酪酸菌制剂前后的肠道菌群变化

目的:肠易激综合征(IBS)常合并存在肠道菌群失调,缺乏特效疗法。酪酸菌(Cb)是一种含有耐酸性芽胞的微生态制剂,本研究用于治疗IBS,观察酪酸菌制剂的临床疗效及肠道菌群状况。方法:从门诊随机选择21例男性,9例女性。检测大便常见菌群和病原菌,采用Miles-Misro介绍的滴注法操作。每次培养时均选上述细菌标准菌株一同培养作质控。结果:治疗前总厌氧菌、双歧杆菌和乳酸杆菌下降,而有潜在致病性的梭菌明显上升,无致病菌生长。治疗后腹泻次数明显减少,总有效率为83.4％,双歧杆菌和乳酸杆菌升高明显。结论:IBS易致肠菌失调。酪酸菌能抑制肠道内腐败菌、病原菌,并能促进双歧杆菌,乳酸菌等肠道内的有益菌发育。

Intestinal Floral Changes in Patients with Irritable Bowel Syndrome after Ingestion of Clostridium Butyricum Preparation

Background/Aims: Intestinal floral disturbance often exists in patients with IBS. There is no effective specific treatment of the disease yet, Clostridium butyricum (Cb) has shown some of its therapeutic effect. Methods: Thirty outpatients were selected randomly to the study. Twenty-one were males and nine females. Normal bacteria flora and pathogenic bacteria in feces of patients were examined. Bacterial counting adopted Miles-Misro methods. Standard bacterial strains of all examined bacteria were incubated, as quality control. Results: Before treatment, the total anaerobes, bifidobacterorioe and lactobacilli in patients with IBS decreased while the potential pathogenic clostridia increased significantly. No pathogen was found in individuals of either groups. After tratment, the number of daily bowel movement decreased, the global response rate was 83.4%. The number of bifidobacteria and lactobacilli increased significantly in patients with IBS. Conclusions: There is disturbance in intestinal flora of patients with IBS. Cb can modulate the intestinal flora and revert it to a normal balance status by inhibiting the intestinal putrifactive, pathogenic bacteria and promoting the growth of beneficial ones sach as bifidobacteria and lactobacilli.