注射用辅酶A、三磷酸腺苷二钠及肌苷注射液配伍稳定性考察

摘 要 目的：考察注射用辅酶A、三磷酸腺苷二钠注射液及肌苷注射液在5%葡萄糖注射液中的配伍稳定性。 方法: 在室温条件下，模拟临床用药方法，配制3种药物与5%葡萄糖注射液的配伍溶液，采用HPLC法测定辅酶A、三磷酸腺苷二钠和肌苷的含量及有关物质变化情况，同时考察配伍溶液的外观、pH和不溶性微粒的变化情况。结果: 室温下4 h内，配伍溶液的外观、pH、不溶性微粒、各药物含量及有关物质均无明显变化；24 h后，配伍溶液出现浑浊絮状物，pH、不溶性微粒、含量及有关物质均明显发生变化。结论:在室温条件下，注射用辅酶A、三磷酸腺苷二钠注射液及肌苷注射液在5%葡萄糖注射液中的配伍溶液应于4 h内使用完。

Study on Compatible Stability of Coenzyme A for Injection, Adenosine Disodium Triphosphate and Inosine Injection

ABSTRACT Objective: To study the compatibility and stability of coenzyme A for injection, adenosine disodium triphosphate and inosine injection. Methods:By simulating the clinical medication, the three drugs and 5% glucose injection were mixed together. The contents and relative substances of coenzyme A, adenosine disodium triphosphate and inosine were measured by HPLC. The changes in appearance, pH and insoluble particles were observed or tested at ambient temperature. Results:The mixed solution showed no significant changes in appearance, pH, number of insoluble particles, contents and relative substances of coenzyme A, adenosine disodium triphosphate and inosine in 4 h, while the mixed solution became turbid and the pH, number of insoluble particles and contents of the three drugs showed significant changes after 24 h storage. Conclusion:The mixed solution of coenzyme A for injection, adenosine disodium triphosphate and inosine injection in 5% glucose injection should be used up in 4 h at ambient temperature.