鸡冠花提取物和钙对氟中毒大鼠骨密度及尿矿物质含量的影响

为了研究鸡冠花对大鼠氟中毒的预防效果,选用雄性ＳＤ大鼠４０只,随机均分为５组。阴性对照组（ＮＣ）喂基础饲料及自来水;其余４组喂基础饲料及高氟水。除单纯加氟组（Ｆ组）外,其他组每千克饲料中分别补加鸡冠花提取物（ＦＣ）、高钙饲料（ＦＣａ）、高钙加鸡冠花提取物（ＦＣＣａ）。实验８周后,测骨矿物含量（ＢＭＣ）和骨密度（ＢＭＤ）、血清钙、２４ｈ尿钙、钠、钾、氟、羟脯氨酸（ＨＯＰ）及尿肌酐含量。结果所有高氟组血清钙及尿钙、尿钠、尿ＨＯＰ及尿氟高于正常对照组,高钙组尿钙高于正常对照组。Ｆ组体重、ＢＭＣ及ＢＭＤ低于正常对照组,ＦＣ、ＦＣａ,ＦＣＣａ组体重高于Ｆ组,ＦＣＣａ组的ＢＭＣ及ＢＭＤ高于Ｆ组。提示饮食高氟可影响大鼠骨密度及矿物质代谢,补钙可减少高氟所造成的影响,补钙加鸡冠花提取物效果更好。

Effect of calcium and cristata L extracts on bone mineral density and urinary mineral of rats

In order to study the effect of cristata L for preventing fluoride toxicity,forty male SD rats were randomly divided into five groups.The control group(NC) was fed with staple feed stuff and tap water,the other four groups were fed with staple feed stuff and high fluorine water. Except the high fluorine group(F),the other groups were fed with cristata L(FC),high calcium(FCa)and cristata L with high calcium(FCCa) respectively.The results showed that the serum calcium,urinary sodium,calcium,hydroxyproline(HOP) and fluorine contents of high fluorine groups were higher than that of control group;and the urinary calcium content of high calcium group was higher than that of control group.The body weight,BMC and BMD of high fluorine groups was lower than that of control group.The weight of groups FC,FCa and FCCa were significantly higher than that of group F.The BMC and BMD of group FCCa were significantly higher than that of group F.This implies that the food high in fluorine can affect the bone mineral density and urinary minerals of rats,the food supplemented with calcium can reduce the effect of high fluorine,and the food supplemented with both calcium and cristata L is better.