羟苯磺酸钙治疗慢性肾功能衰竭的临床观察与实验研究

目的观察羟苯磺酸钙对慢性肾功能衰竭（肾衰）的治疗作用，探讨该药对肾脏的保护机制，从而初步评价其治疗慢性肾衰的应用价值。方法 临床观察部分：选取131例慢性肾衰患者，分为两组：①治疗组73例，在常规综合治疗的基础上加用羟苯磺酸钙胶囊0．5g．3次／d；②对照组58例，采用常规综合治疗，观察8周内两组患者肾功能的变化。动物实验部分：建立5／6肾切除大鼠慢性肾衰模型，设立假手术组、5／6肾切除组以及羟苯磺酸钙组，治疗12周后观察大鼠肾功能以及残肾组织病理改变。结果临床观察部分：治疗2周后，患者血肌酐（Scr）即明显降低，内生肌酐清除率（Ccr）上升，并维持至第8周；血尿酸（UA）治疗后明显降低。动物实验部分：12周后，与5／6肾切除组比较．羟苯磺酸钙组大鼠肾功能改善，残肾组织病理改变明显减轻。结论羟苯磺酸钙能够抑制肾脏纤维化的进展，改善肾脏功能，任慢性肾功能衰竭的治疗方面具有一定的应用价值。

Effects of Calcium Dobesilate in Treatment of Chronic Renal Failure

Objective To observe the effects of calcium dobesilate in the treatment of chronic renal failure(CRF) and the mechanism.Methods 131 patients with CRF were divided into two groups: Treatment group including 73 patients received calcium dobesilate(0.5 g,tid) in addition to the routine complicated therapy;control group with 58 patients only received the routine complicated therapy.The serum cretonne,serum BUN and uric acid in the patients were measured during 8 weeks.The model of CRF was induced by 5/6 nephrectomy in SD rats.Rats were divided into three groups: Sham group,5/6 nephrectomized group,5/6 nephrectomized and calcium dobesilate therapy group.After 12 weeks,renal function and renal pathological change of the remnant kidney in the model animals were examined.Results The renal function of the patients was improved obviously after treatment for 2 weeks and stable till 8th week.In animal experiments,the renal function and pathological change of remnant kidney in the treatment group were significantly improved as compared with 5/6 nephrectomized group.Conclusion Calcium dobesilate could protect renal function by improving pathological change of CRF.It was suggested that calcium dobesilate had great effects on CRF.