氟伐他汀对糖尿病大鼠肾脏CTGF表达的影响

目的：研究氟伐他汀对糖尿病大鼠肾组织CTGF表达的影响,探讨氟伐他汀肾脏保护作用的机制。方法：SD雄性大鼠54只,随机分为：正常对照组（N组）、糖尿病对照组（D组）、糖尿病氟伐他汀治疗组（4 mg.kg-1.d-1）（F组）。由大鼠尾静脉单次注射链脲佐菌素（60 mg/kg）,造成糖尿病大鼠模型。经氟伐他汀治疗糖尿病大鼠2、4、8周后,分别观察其对大鼠血糖、血胆固醇、血肌酐、24 h尿蛋白定量和肾皮质CTGF表达的影响。结果：与正常对照组相比,糖尿病大鼠24 h尿蛋白定量、血胆固醇及肾组织CTGF表达显著增加;经氟伐他汀治疗后,糖尿病大鼠的24 h尿蛋白定量、胆固醇和CTGF表达下降。结论：糖尿病大鼠肾组织CTGF表达增加,氟伐他汀可能通过下调糖尿病大鼠肾脏CTGF表达而达到部分肾脏保护作用。

Effect of Fluvastatin on CTGF Expression in Renal Tissue of Diabetic Rats

Objective:It is to study the effect of fluvastatin on connective tissue growth factor(CTGF) in the renal tissue of diabetic rats and to explore the mechanism of fluvastatin in the renal protective effect. Methods:54 male SD rats were randomly divided into three groups: normal control group(N group),streptozotocin diabetic rats(D group),diabetic rats treated with fluvastatin(4 mg·kg-1·d-1)(F group).The diabetic rats models were induced by a single injection of streptozotocin(60 mg/kg)via coccygeal vein.The levels of blood glucose,plasma cholesterol,plasma creatinine,excretion of 24 h urinary protein and CTGF in the renal tissue were measured after 2,4,8 weeks of treatment. Results:24 h urinary protein,plasma cholesterol and expressions of CTGF in D group and F group were significantly increased than those in N group.They were decreased in F group after fluvastatin treatment than those in D group. Conclusion:The expressions of CTGF were highly increased in the renal tissue of diabetic rats.Fluvastatin has some renal protective effects in diabetic rats,partly through down-regulating the CTGF expressions.