| STAT3在大肠癌中的表达及其临床意义 |
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| 引用本文： | 张国强,曹立宇. STAT3在大肠癌中的表达及其临床意义[J]. 安徽医药, 2012, 16(10): 1442-1443 |
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| 作者姓名： | 张国强 曹立宇 |
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| 作者单位： | 1. 安徽省太和县中医院病理科,安徽,太和,236607
2. 安徽医科大学病理学教研室,安徽,合肥,230032 |
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| 基金项目： | 安徽省自然科学基金面上项目(No 090413098);安徽省高等学校省级自然科学研究重点项目(No KJ2009A76) |
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| 摘 要： | 目的 探讨信号转导子与转录活化子3(STAT3)在大肠癌组织中的表达,及其与临床病理因素间的关系.方法 应用免疫组织化学S P方法检测STAT3在50例大肠癌组织中的表达情况.结果 STAT3蛋白在大肠癌组织中的阳性表达率分别是68%(34/50)明显高于大肠正常黏膜组织35%(7/20).STAT3蛋白表达与淋巴结转移及临床Duke's分期有关,与患者年龄、性别及肿瘤分化程度、浸润深度无关.结论 STAT3在大肠癌的发生发展中具有重要作用.
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| 关 键 词： | 大肠癌 STAT3 免疫组织化学 |
Expression and clinical significance of STAT3 in colorectal carcinoma |
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| ZHANG Guo-qiang , CAO Li-yu. Expression and clinical significance of STAT3 in colorectal carcinoma[J]. Anhui Medical and Pharmaceutical Journal, 2012, 16(10): 1442-1443 |
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| Authors: | ZHANG Guo-qiang CAO Li-yu |
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| Affiliation: | 1.Department of Pathology,Chinese Medical Hospital of Taihe County,Taihe 236607,China; 2.Department of Pathology,Anhui Medical University,Hefei 230032,China) |
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| Abstract: | Objective To investigate the expression and clinical significance of STAT3 in colorectal carcinoma(CRC).Methods Immunohistochemical staining(S-P method) for STAT3 protein was performed in 50 CRC.Results The positive rates of STAT3 in CRC(64.5%) were higher than those in normal mucosa(35%)(P<0.05).The expression of STAT3 protein was correlated with lymphnode metastasis and Dukes stage.Conclusion STAT3 protein plays an important role in the carcinogenesis of CRC. |
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| Keywords: | colorectal carcinoma STAT3 immunohistochemistry |
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