中西医结合治疗溃疡性结肠炎疗效分析

目的 观察康复新液联合柳氮磺吡啶保留灌肠治疗溃疡性结肠炎（UC）的临床疗效.方法 88例UC患者随机分为两组：对照组47例,予柳氮磺吡啶（SASP）保留灌肠,每晚1次;实验组41例,在对照组基础上加用康复新液保留灌肠,每日上午1次;疗程均为4周.观察患者临床症状及治疗后4周结肠镜下黏膜改善情况.结果 实验组临床疗效及结肠镜下疗效均优于对照组,组间差异有统计学意义（uc=2.09、2.25,P＜0.05）.实验组临床近期痊愈率及结肠镜下近期痊愈率分别为43.90％、39.02％,均高于对照组的29.79％、25.53％,但组间差异无统计学意义（x2=1.88、0.23,P＞0.05）;实验组临床疗效及结肠镜下总有效率分别为75.61％、73.17％,明显高于对照组的51.06％、51.06％,组间差异无统计学意义（x2=5.63、6.30,P＜0.05）.结论 康复新液联合柳氮磺吡啶保留灌肠治疗UC的疗效明显优于单独使用柳氮磺吡啶保留灌肠者,值得临床推广.

Clinical study on the treatment of ulcerative colitis with integrated traditional Chinese and western medicine

Objective To observe the clinical effect of KangfiLxin combined with sulfasalazine retention-ene- ma for ulcerative colitis （UC）. Methods Eighty-eight UC patients were randomly divided into two groups： the con- trol group （n=47, treated with retention-enema with sulfasalazine （SASP）, QN; 41 cases, the study group （n=41, treated with retention-enema with KangfiLxin solution on the basis of the control group, Qd）. The treatment course was 4 weeks. The clinical symptoms and improvments in mucosa under colonoscope after treatment were observed. Results The study group was better than the control group in the clinical curative effect and colonoscopy （uc=2.09, 2.25, P〈0.05）. The recovery rates of clinical symptoms and colonoscopy in the study group （43.90% and 39.02%） were higher than those in the control group （29.79% and 25.53%）, Z2=1.88, 0.23,/〉〉0.05. The total effective rates of the clinical symp- toms and the colonoscopy in the study group （75.61% and 73.17%） were higher than those in the control group （51.06% and 51.06%）, x=5.63, 6.30, P〈0.05. Conclusion Kangfuxin combined with sulfasalazine retention-enema is better than simple use of sulfasalazine in the treatment of UC effect. The former method is worthy of clinical application.