早期连续静推纳络酮对新生儿缺氧缺血性脑病预后的影响

目的 探讨早期连续使用纳洛酮对新生儿缺氧缺血性脑病（HIE）的的治疗效果和预后的影响.方法 将2004年11月至2011年9月在本院进行治疗的110例缺氧缺血性脑病患儿随机分为对照组和治疗组,每组55例.对照组仅给予常规治疗,治疗组在对照组的基础上,每天给予加用纳洛酮治疗,疗程为3～5 d.对两组的疗效和预后的影响进行比较分析.结果 治疗组的总有效率为90.91％,显著高于对照组的76.36％ （P＜0.05）;患儿随访12个月后的发育指标评分比较,治疗组均显著高于对照组（P＜0.05）.结论 在常规治疗新生儿HIE的基础上加用纳络酮,可显著改善HIE患儿病情,提高患儿的存活率,减少后遗症的发生.

Effect of early continuous intravenous injection of naioxone on the prognosis of neonatal hypoxic ischemic encephalopathy

Objective To discuss the influence of early continuous intravenous injection of naloxone on the clinical prognosis of neonatal hypoxic ischemic encephalopathy （HIE）. Methods One hundred and ten newborns with HIE in our hospital from November 2004 to September 2011 were randomly divided into the treatment group （n=55） and the control group （n=55）. Traditional treatment was applied in the control group, and Naloxone （0.03-0.05 mg/kg, 3-5 days） was added in the treatment group on the basis of traditional treatment. The clinical efficacy and prognosis were compared between the two groups. Results The total effective rate of the treatment group was 90.91%, signifi- cantly higher than that of the control group （76.36%）, P〈0.05. After 12 months of follow-up, the scores of growth in- dexes in the trealrnent group were significantly higher than those in the control group. Conclusion The therapy with naloxone on the basis of traditional treatment can markedly improve the severity and increase the survival rate of new- born with HIE.