Molecular factors promoting carcinogenesis and malignant behavior of intraductal papillary mucinous tumors |
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| Authors: | Ichikawa Yasushi Ueda Michio Miura Yasuhiko Kunihiro Satoshi Ishikawa Takashi Endo Itaru Sekido Hitoshi Shimada Hiroshi |
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| Affiliation: | Department of Surgery-II, Yokohama City University, School of Medicine, Yokohama, Japan. |
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| Abstract: | ![]()
Many molecular factors related to the carcinogenesis and malignant behavior of pancreatic cancer were identified by investigation of intraductal papillary mucinous tumors (IPMTs). Molecules controlling the G1/S phase, such as p53, p21, p61, and cyclin D1, tumor suppressors including DPC-4, and many other factors such as MUC-1/2 contribute to the promotion of the malignant behavior of IPMTs. They will be important molecular targets for the radical treatment of pancreatic cancer. |
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