叶酸干预血管内皮功能障碍的研究进展

血管内皮功能障碍与诸多心血管疾病的发生、发展有密切联系,被认为是心血管疾病危险的终点替代指标。内皮功能障碍的研究和血管内皮的保护成为目前研究的热点。叶酸,一种经济无毒的药物,能明确改善血管内皮功能。其可能机制有降低血浆同型半胱氨酸、抗氧化作用、对内皮型一氧化氮合酶作用等,其对心血管疾病的预防具有重要意义。

Folates Therapy on Endothelial Dysfunction

Endothelial dysfunction is closely related to occurrence and progress of many cardiovascular diseases,and has been recognized as a surrogate end point for cardiovascular risk.At present,the study of endothelial dysfunction and protection of endothelium have become the focused issues.Folate,a kind of economical and nonpoisonous drugs,can definitely improve vascular endothelial function.The potential mechanisms underlying a beneficial effect of folic acid in cardiovascular disease include the homocysteine-lowering effects,antioxidant action,or direct interactions with the enzyme endothelial nitric oxide synthase.Folates have the significant effects in the prevention of cardiovascular disease.