| 细胞周期素D1基因多态性及幽门螺杆菌感染与胃癌易感性的关系 |
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| 引用本文： | 刘耀煌,方向明,彭威,方志军.细胞周期素D1基因多态性及幽门螺杆菌感染与胃癌易感性的关系[J].武汉大学学报(医学版),2009,30(3). |
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| 作者姓名： | 刘耀煌 方向明 彭威 方志军 |
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| 作者单位： | 1. 湖北省黄石市第四医院检验科,湖北,黄石,435006
2. 武汉市第三医院消化内科,湖北,武汉,430060 |
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| 摘 要： | 目的:研究细胞周期素D1(Cyclin D1)基因多态性与胃癌易感性的关系,同时探讨Cyclin D1基因多态性及其与幽门螺杆菌(Hp)感染联合作用对胃癌发病风险的影响。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测115例胃癌与112例慢性胃炎患者(对照组)Cyclin D1基因第870位核苷酸A/G(A870G)多态性,应用ELISA方法检测上述人群中Hp感染率。结果:胃癌组Cyclin D1基因型频率与对照组比较,差异有显著性(P<0.05)。与AG及GG基因型携带者之和相比,AA基因型携带者患胃癌的相对风险度(OR)为2.60,95%可信区间(CI)为1.47-4.58。Hp阳性胃癌组Cyclin D1基因型频率与Hp阳性对照组比较,差异亦有显著性(P<0.05)。与AG及GG基因型携带者之和相比,携带AA基因型的Hp阳性者患胃癌的OR为3.82,95%CI为1.92-7.61。结论:Cyclin D1基因多态性与胃癌遗传易感性有关,携带Cyclin D1 AA基因型个体患胃癌的危险性增高。Hp感染和Cyclin D1基因多态性有协同促进胃癌发生的作用。
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| 关 键 词： | 胃肿瘤 细胞周期素D1 基因多态性 幽门螺杆菌 |
Relation of Cyclin D1 Gene Polymorphism and Helicobacter Pylori Infection to Gastric Cancer |
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| LIU Yaohuang,FANG Xiangming,PENG Wei,FANG Zhijun.Relation of Cyclin D1 Gene Polymorphism and Helicobacter Pylori Infection to Gastric Cancer[J].Medical Journal of Wuhan University,2009,30(3). |
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| Authors: | LIU Yaohuang FANG Xiangming PENG Wei FANG Zhijun |
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| Institution: | LIU Yaohuang1,FANG Xiangming2,PENG Wei1,FANG Zhijun11Dept.of Clinical Laboratory,Huangshi Fourth Hospital,Huangshi 435006,China2Dept.of Gastroenterology,Wuhan Third Hospital,Wuhan 430060,China |
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| Abstract: | Objective: To investigate the relationship between Cyclin D1 gene polymorphism and susceptibility of gastric cancer,and to evaluated the combined effect of Cyclin D1 gene polymorphism and Helicobacter pylori(Hp) infection on gastric cancer.Methods: By polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),the Cyclin D1(A870G) genotyping was performed among 115 cases with gastric cancer and 112 controls with chronic gastritis.ELISA was adapted to examine Hp infection of the above patien... |
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| Keywords: | Stomach Neoplasms Cyclin D1 Gene Polymorphism Helicobacter Pylori |
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