| 凝血酶原G20210A突变与冠心病的相关性研究 |
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| 引用本文： | 李莉,刘瑞云,李锦堂.凝血酶原G20210A突变与冠心病的相关性研究[J].血栓与止血学,2005,11(3):106-108. |
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| 作者姓名： | 李莉 刘瑞云 李锦堂 |
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| 作者单位： | 郑州大学第一附属医院,郑州,450052 |
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| 摘 要： | 目的探讨凝血酶原基因G20210A突变与中国汉族人群冠心病的相关性。方法采用PCR-RFLP技术检测145例冠心病患者和126例健康对照者凝血酶原G20210A突变，计算病例组与对照组的基因型频率、等位基因频率以及突变与冠心病的相关性。结果病例组和对照组均未发现凝血酶原G20210A突变基因携带者。结论凝血酶原基因G20210A突变不是中国汉族人群冠心病的主要致病因素。
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| 关 键 词： | 凝血酶原 冠心病 突变 |
| 文章编号： | 1009-6213(2005)03-106-03 |
| 修稿时间： | 2004年5月20日 |
Study on the Mutation of Prothrombin G20210A in Patients with Coronary Heart Disease |
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| LI Li,LIU Rui-yun,LI Jin-tang.Study on the Mutation of Prothrombin G20210A in Patients with Coronary Heart Disease[J].Chinese Journal of Thrombosis and Hemostasis,2005,11(3):106-108. |
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| Authors: | LI Li LIU Rui-yun LI Jin-tang |
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| Abstract: | Objective To investigate a possible association between the mutation of human prothrombin gene G20210A and coronary heart disease (CHD). Methods Blood samples were obtained from 145 patients with coronary heart disease and 126 healthy controls. The genotypes of prothrombin at position 20210 were determined by PCR-RFLP. Results No mutation of prothrombin G20210A was found in patients and controls. Conclusion The mutation of prothrombin G20210A is unlikely to be an independent risk factor for coronary heart disease in Chinese population. |
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| Keywords: | Prothrombin Coronary heart disease Mutation |
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