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侵袭性肺曲霉病的临床特征分析
引用本文:刘丹丹,陈慧,邵长周,何礼贤. 侵袭性肺曲霉病的临床特征分析[J]. 中国临床医学, 2014, 0(5): 540-542
作者姓名:刘丹丹  陈慧  邵长周  何礼贤
作者单位:1. 复旦大学附属中山医院呼吸科,上海 200032; 安徽省第二人民医院呼吸科,安徽合肥 230041
2. 浙江省金华市中心医院呼吸科,浙江金华,321000
3. 复旦大学附属中山医院呼吸科,上海,200032
基金项目:上海市自然科学基金项目(编号13ZR1406600);浙江省金华市科学技术局社发重点计划项目
摘    要:
目的:探讨侵袭性肺曲霉病(invasive pulmonary aspergillosis,IPA)的临床特征。方法:回顾分析83例IPA患者的临床及影像学资料。结果:IPA患者的主要临床表现为发热、咳嗽、咳痰、喘息、呼吸困难、咯血。IPA患者的影像学表现多样,典型表现如晕征和新月征则较少见(主要见于免疫抑制患者)。83例中原发性IPA患者18例,均治愈;继发性IPA患者65例,治愈23例,好转出院25例,患者要求出院12例,病死5例。结论:IPA好发于有基础疾病和免疫抑制的患者,其临床和影像学表现不典型;原发性IPA较继发性IPA预后好。

关 键 词:侵袭性肺曲霉病  影像学  临床特征

Clinical Manifestations and Imaging Findings of Patients with Invasive Pulmonary Aspergillosis
LIU Dan-dan,CHEN Hui,SHAO Changzhou,HE Lixian. Clinical Manifestations and Imaging Findings of Patients with Invasive Pulmonary Aspergillosis[J]. Chinese Journal Of Clinical Medicine, 2014, 0(5): 540-542
Authors:LIU Dan-dan  CHEN Hui  SHAO Changzhou  HE Lixian
Affiliation:LIU Dan- dan, CHEN Hui, SHAO Changzhou, HE Lixian(1. Department of Respiratory Medicine, Zhongshan Hospital ,Fudan University, Shanghai 200032, Chinal 2. Department of Respiratory Med- icine, Second People's Hospital of Anhui Province, He f ei 230041, China 3. Department of Respira- tory Medicine, Jinhua Central Hospital, Jinhua 321000, China)
Abstract:
Objective:To investigate the clinical features of invasive pulmonary aspergillosis (IPA).Methods:The clinical fea-tures and imaging characteristics of 83 patients with IPA were retrospectively and comparatively analyzed.Results:The clinical manifestations of IPA included fever,cough,sputum,wheezing,dyspnea,hemoptysis.Imaging findings in patients with IPA were diverse.Typical manifestations such as Halo sign and crescent sign were rare,which were mainly observed in immuno-suppressed patients.All of the 18 cases of primary IPA were cured.Among the 65 secondary IPA patients,23 cases were cured,25 cases improved and discharged,12 cases discharged without medical advice,and 5 cases died.Conclusions:IPA oc-curred often in patients with underlying diseases and immune suppression,having atypical clinical manifestations and imaging findings.Patients with primary IPA have better prognosis than those with secondary IPA.
Keywords:Invasive pulmonary aspergillosis  Imaging findings  Clinical features
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