Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report |
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| Authors: | Catherine Butori Véronique Hofman Rita Attias Jerôme Mouroux Florence Pedeutour Paul Hofman |
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| Affiliation: | (1) Laboratory of Clinical and Experimental Pathology and Human Tissue Biobank Unit, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002 Nice, France;(2) Laboratory of Solid Tumors Genetics, Centre Hospitalier Universitaire de Nice and CNRS UMR 6543, Faculté de Medecine, Nice, France;(3) Department of Thoracic Surgery, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002 Nice, France |
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| Abstract: | ![]()
Synovial sarcoma (SS) is an uncommon soft tissue tumor occurring mainly in the periarticular region of the extremities of young adults. In this report, we describe a very rare occurrence of primary SS of the esophagus in a 72-year-old woman. Histologically, the tumor demonstrated biphasic morphologic findings associated with poorly differentiated areas. Tumor cells expressed vimentin, epithelial (EMA, CK7, AE1/3), bcl-2 and neuroectodermal (CD56, CD57, CD99) antigens. Differential diagnose included esophageal sarcomatoid carcinoma. Cytogenetic analysis confirmed the diagnosis of SS by identifying t(X;18) translocation. The literature of this very uncommon entity of the esophagus is reviewed. |
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| Keywords: | Oesophagus Sarcoma Cytogenetic Fluorescence in situ hybridization Sarcomatoid carcinoma |
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