| 阿德福韦在预防肝移植后乙肝复发中的作用 |
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| 引用本文： | 张雅敏,朱志军,郑虹,邓永林,蒋文涛,蔡金贞,沈中阳. 阿德福韦在预防肝移植后乙肝复发中的作用[J]. 中华肝胆外科杂志, 2006, 12(5): 313-315 |
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| 作者姓名： | 张雅敏 朱志军 郑虹 邓永林 蒋文涛 蔡金贞 沈中阳 |
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| 作者单位： | 300192,天津市,天津第一中心医院器官移植中心 |
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| 摘 要： | 目的评价adefovir在预防肝移植后乙肝复发中的应用效果及安全性.方法统计30例应用lamivudine出现耐药及病毒变异的肝移植病例加用adefovir后病人：ALT、HBV-DNA、Cr以及HBeAg的变化,以及观察adefovir的副作用.结果应用adefovir12周后,ALT恢复正常者占65.5%,HBVDNA转阴（＜10^4拷贝/ml）占76.7%,HBeAg转阴44%,未发现严重的肾功能异常及其它副作用.结论肝移植术后应用lamivudine出现耐药及病毒变异病例,及时加用adefovir可有效改善肝功能、抑制肝炎复发.
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| 关 键 词： | 肝移植 adefovir 乙肝复发 |
| 收稿时间： | 2005-03-10 |
| 修稿时间： | 2005-06-28 |
Role of adefovir in prevention of hepatitis B recurrence after liver transplantation |
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| ZHANG Yamin,ZHU Zhijun,ZHENG Hong. Role of adefovir in prevention of hepatitis B recurrence after liver transplantation[J]. Chinese Journal of Hepatobiliary Surgery, 2006, 12(5): 313-315 |
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| Authors: | ZHANG Yamin ZHU Zhijun ZHENG Hong |
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| Affiliation: | Organ Transplantation Center, Tianjin First Central Hospital, Tianjin 300192, P. R. China |
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| Abstract: | Objective To determine the effectiveness and safety of adefovir in treatment of hepatitis B recurrence after liver transplantation. Methods After the liver transplantation, adefovir was administered to 30 lamivudine-resistant patients with viral mutation for 12 weeks. Then the changes in ALT, HBV-DNA, Cr and HBeAg were determined and the side effect of the drug observed. Results The ALT became normal in 65.5%, HBV-DNA was negative in 76.7% and HBeAg was negative in 44% of the patients. Meanwhile, no serious side effect of the drug was found. Conclusions Adefovir is an effective drug for treatment of hepatitis B recurrence after liver transplantation. |
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| Keywords: | Liver transplantation Adefovir Hepatitis B recurrence |
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