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| Correlation between Blood cAMP, cGMP Levels and Traumatic Severityin the Patients with Acute Trauma and Its Clinical Significance | |
| 引用本文： | 白祥军,王海平,李占飞,刘开俊. Correlation between Blood cAMP, cGMP Levels and Traumatic Severityin the Patients with Acute Trauma and Its Clinical Significance[J]. 华中科技大学学报(医学英德文版), 2004, 24(1): 68-70. DOI: 10.1007/BF02830710 |
| 作者姓名： | 白祥军 王海平 李占飞 刘开俊 |
| 作者单位： | Department of Traumatology，Department of Traumatology，Department of Traumatology，Department of Traumatology Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030 |
| 摘 要： | Atpresent,therearemanymethodsusedtoas sesstheseverityoftrauma ,suchasAIS ISS ,TS ,RTS ,ASCOT ,PHIandsoon ,intermsoftheinjuryofanatomicregions ,changesin phathophysiology ,agesetc .,butnotinvolvingthechangesofstressre sponsesofwholebodyatcellularandmolecul… |
| 关 键 词： | 急性创伤 cAMP cGMP 白细胞 血小板 血清学检查 病情评估 临床意义 |
| 收稿时间： | 2003-11-19 |
Correlation between blood cAMP,cGMP levels and traumatic severity in the patients with acute trauma and its clinical significance |
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| Bai Xiangjun,Wang Haiping,Li Zhanfei,Liu Kaijun. Correlation between blood cAMP,cGMP levels and traumatic severity in the patients with acute trauma and its clinical significance[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2004, 24(1): 68-70. DOI: 10.1007/BF02830710 | |
| Authors: | Bai Xiangjun Wang Haiping Li Zhanfei Liu Kaijun |
| Affiliation: | Department of Traumatology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 |
| Abstract: | Summary In order to investigate the correlation between traumatic servity and blood cAMP and cGMP levels in the patients with acute trauma and its clinical significance, 120 cases of trauma were randomly selected and divided into 4 groups (n=30 in each group): mildly traumatic group (ISS≤9), moderately traumatic group (ISS=10–16), severely traumatic group (ISS=17–25) and dangerously traumatic group (>25). The cAMP and cGMP levels were assayed in sera, leucocytes and platelets respectively in 6 h and 24 h after trauma. The results showed that cAMP and cGMP levels were elevated significantly in sera and platelets (P<0.05 orP<0.01), meanwhile cGMP levels in leucocytes (P<0.05). It was concluded that cAMP and cGMP might play an important role in traumatic stress, participate in the cellular signal transducation and promote the immune function of leucocytes and the coagulation founction of platelets. Serum cAMP and cGMP levels were upregulated correspondingly as ISS increased, and positively correlated to the traumatic severity. BAI Xiangjun, male, born in 1963, M. D., Ph. D. Associate Professor |
| Keywords: | cAMP cGMP trauma |
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