| 湿地真菌Talaromyces flavus中2个新的聚酯类化合物 |
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| 引用本文： | 何军伟,高昊,刘杏忠,姚新生.湿地真菌Talaromyces flavus中2个新的聚酯类化合物[J].中国中药杂志,2015,40(17):3347-3351. |
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| 作者姓名： | 何军伟 高昊 刘杏忠 姚新生 |
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| 作者单位： | 暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632;江西中医药大学 中药资源与民族药研究中心, 江西 南昌 330004,暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632,中国科学院 微生物研究所 真菌学国家重点实验室, 北京 100101,暨南大学 药学院 中药及天然药物研究所, 广东 广州 510632 |
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| 基金项目： | 国家自然科学基金项目(81422054) |
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| 摘 要： | 从一株蓝状菌属真菌Talaromyces flavus(No.BYD07-13)固体发酵物中分离得到了2个聚酯类新化合物talapolyesters G~H(1~2),采用质谱和核磁共振谱确定了它们的结构。化合物 1~2 的绝对构型是通过碱水解确定。对化合物 1~2 还评价对5株肿瘤细胞(HL-60, SMMC-7721, A-549, MCF-7, SW480)的生长抑制活性。
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| 关 键 词： | 湿地真菌 黄蓝状菌 talapolyesters G~H 细胞毒活性 |
| 收稿时间： | 2015/5/25 0:00:00 |
Two new polyesters from wetland soil-derived fungus Talaromyces flavus |
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| HE Jun-wei,GAO Hao,LIU Xing-zhong and YAO Xin-sheng.Two new polyesters from wetland soil-derived fungus Talaromyces flavus[J].China Journal of Chinese Materia Medica,2015,40(17):3347-3351. |
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| Authors: | HE Jun-wei GAO Hao LIU Xing-zhong and YAO Xin-sheng |
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| Institution: | Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China;Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China,Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China,State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China and Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Ji'nan University, Guangzhou 510632, China |
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| Abstract: | Two new polyesters, talapolyesters G-H(1~2) were isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13, and their structures were determined by NMR and MS spectroscopic data. The absolute configurations of the residues were determined by alkaline hydrolysis. The cytotoxicity against five tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7 and SW480) of 1~2 was examined. |
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| Keywords: | wetland soil-derived fungus Talaromyces flavus talapolyerters G-H cytotoxicity |
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