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益气养阴活血通腑法治疗2型糖尿病磺脲类药继发性失效的临床观察
引用本文:陈苹,朱章志,郎江明,魏爱生,陈发胜. 益气养阴活血通腑法治疗2型糖尿病磺脲类药继发性失效的临床观察[J]. 中国中西医结合杂志, 2004, 24(7): 585-588
作者姓名:陈苹  朱章志  郎江明  魏爱生  陈发胜
作者单位:1. 广东省佛山市中医院糖尿病强化治疗中心,广东,528000
2. 广州中医药大学第一附属医院糖尿病研究所
摘    要:目的 观察益气养阴活血通腑法治疗2型糖尿病磺脲类药继发性失效(SFS)的疗效。方法 40例患者随机分为两组,两组均在原磺脲类药剂量不变的情况下,中药组加服益气养阴活血通腑汤剂治疗,西药组加服罗格列酮治疗。观察治疗前后外周血胰岛素敏感度(SI)、胰岛素释放率(IRG)、胰岛素敏感性指数(ISI)、肿瘤坏死因子α(TNFα)、内皮素-1(ET-1)、6-酮-前列腺素F1α(6-keto-PGF1α)和血栓素B2(TXB2)等指标的变化。结果 (1)中药组降糖的总有效率为71、4%,改善外周胰岛素抵抗的总有效率为76.2%,与西药组相仿。(2)中药组SI与ISI显著改善(P<0、05),IRG无明显改善。(3)中药组TNFα、ET-1、TX&明显下降(P<0.05或P<0.01)。结论 益气养阴活血通腑法可减轻SFS患者的外周胰岛素抵抗,抑制TNFα,保护血管内皮细胞。

关 键 词:益气养阴活血通腑法  2型糖尿病  磺脲类  继发性失效  SFS  并发症
修稿时间:2003-08-07

Clinical Observation on Effect of Yiqi Yangyin Huoxue Tongfu Principle in Treating Diabetes Mellitus Type 2 of Secondary Failure to Sulfonylurea Agents
CHEN Ping,ZHU Zhang-zhi,LANG Jiang-ming. Clinical Observation on Effect of Yiqi Yangyin Huoxue Tongfu Principle in Treating Diabetes Mellitus Type 2 of Secondary Failure to Sulfonylurea Agents[J]. Chinese journal of integrated traditional and Western medicine, 2004, 24(7): 585-588
Authors:CHEN Ping  ZHU Zhang-zhi  LANG Jiang-ming
Abstract:OBJECTIVE: To observe the effect of Yiqi Yangyin Huoxue Tongfu (YYHT) principle in treating diabetes mellitus type 2 of secondary failure to sulfonylurea agents. METHODS: Forty patients were randomly divided into two groups, based on the unchanged previous treatment of sulfonylurea agents, Chinese decoction prescribed according to YYHT principle was given to the treated group and rosiglitazone was given to the control group. Changes of insulin sensitivity (SI), insulin response to glucose (IRG), insulin sensitive index (ISI), tumor necrosis factor-alpha (TNF-alpha), endothelin-1 (ET-1), 6-keto-prostaglandin F1alpha(6-keto-PGF1alpha) and thromboxane B2 (TXB2) were observed. RESULTS: The total effective rate in the treated group was 71.4%, that on improving peripheral insulin resistance was 76.2%, the two parameters were similar to those in the control group. In the treated group, SI, ISI were significantly improved, and TNF-alpha, ET-1 and TXB2 significantly lowered, but no change of IRR was found. CONCLUSION: Application of YYHT principle in treating patients with diabetes mellitus type 2 of secondary failure to sulfonylurea agents could alleviate the peripheral resistance to insulin, inhibit TNF-alpha, and protect the vascular endothelial cells.
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