不同轴向伸长率下兔股动、静脉的顺应性变化

研究轴向应变对血管顺应性的影响 ,明确能否通过调节吻合张力建立顺应性一致的静脉移植修复动脉缺损模型。取一段做完轴向拉伸实验的血管 (兔股动、静脉分别为 13、12条 ) ,测量不同伸长率下的压力—容积曲线 ,换算为压力—标准容积曲线 ,用幂函数 P=M1 × еM2 ( v- v0 ) - 1]进行拟合 ,用多项式 M=a1 λ5+a2 λ4 +a3λ3+aλ2 +a5λ+a6 拟合 M- λ数据。由 P=M1 × еM2 ( v- v0 ) - 1]得出在动脉平均压 (11.78KPa)下血管顺应性 dv/ dp=1/ (M1 ×M2 +11.78M2 )。由张力 T与伸长率 λ的单值对应关系建立起 T与顺应性 dv/ dp的单值对应关系 ,发现在张力 1.19g时 ,在动脉平均压下 ,动静脉的顺应性一致 ,为 0 .0 31,其所对应的动静脉伸长率为 :1.6 7及 1.32

Compliance Variation Following the Change of Longitudinal Stretch Ratio A Study on Femoral Artery and Vein in a Rabbit Model

This study was aimed to establish a rabbit model of bridging artery defect with autogenous vein under equal arterial and venous compliances by selecting an appropriate anastomosing tension based on assessing the influence of vessel's longitudinal strain on compliance. The exponential form P = M1 x eM2(v-v0)-1] was employed to fit the blood pressure-unit volume curves under different stretch ratios(lambda) obtained from real curves on 13 femoral arteries and 12 veins whose uniaxial loading tests at longitudinal directions had been performed, then the quantic M = a1 lambda 5 + a2 lambda 4 + a3 lambda 3 + a lambda 2 + a5 lambda + a6 was done to fit M-lambda data. Results showed the differential form dv/dp = 1/(M1 x M2 + 11.78 M2) derived from P = M1 x eM2(v-v0)-1], and lambda reflected the relationship between compliance and stretch ratio (or longitudinal tension) under average artery pressure 11.78 KPa well. It was found that under longitudinal tension 1.19 g, the arterial and venous compliances were equal(0.031 microliter/KPa) while the respective stretch ratios were 1.32 and 1.67.