| 丹参酮ⅡA对小鼠肝损伤的保护作用 |
| |
| 引用本文： | 刘永刚,陈厚昌,蒋毅萍,李芳哲. 丹参酮ⅡA对小鼠肝损伤的保护作用[J]. 中药材, 2001, 24(8): 588-589 |
| |
| 作者姓名： | 刘永刚 陈厚昌 蒋毅萍 李芳哲 |
| |
| 作者单位： | 1. 第一军医大学
2. 北华大学医学院附属医院 |
| |
| 摘 要： | 目的：探讨丹参酮ⅡA（tanshinone ⅡA，TSN）对肝脏损伤的保护作用。方法：CCl4和D－半乳糖胺小鼠肝脏损伤模型，以测定血清谷丙氨酸转换酶（ALT）、谷草氨基酸转换酶（AST)肝匀浆丙二醛（MDA）含量为指标观察丹参酮ⅡA对肝脏损伤的保护作用。结果：丹参酮ⅡA与阳性对照药联苯双酯相仿，均能明显降低急性肝损伤小鼠的血清ALT、AST和肝匀浆MDA含量。结论：丹参酮ⅡA具有明显的保肝作用。
|
| 关 键 词： | 丹参酮ⅡA 四氯化碳 D－半乳糖胺 肝损伤 |
| 修稿时间： | 2001-05-25 |
Protective effect of tanshinone IIA on acute hepatic injury in mice] |
| |
| Liu Yonggang,Chen Houchang,Jiang Yiping. Protective effect of tanshinone IIA on acute hepatic injury in mice][J]. Journal of Chinese medicinal materials, 2001, 24(8): 588-589 |
| |
| Authors: | Liu Yonggang Chen Houchang Jiang Yiping |
| |
| Affiliation: | First Military Medical University, Guangzhou 510515. |
| |
| Abstract: | OBJECTIVE: To study the effect of tanshinone IIA on two models of acute hepatic injury in mice. METHODS: Two acute hepatic injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-GalN) in mice were used. ALT, AST in serum and MDA in liver homogenate were used as indexes. RESULTS: Tanshinone IIA (10 mg.kg-1, 20 mg.kg-1, 30 mg.kg-1), similar to biophenyldicarboxylate, could decrease ALT, AST in serum and MDA in hepatic homogenate on acute hepatic injury induced by CCl4 and D-GalN. CONCLUSION: Tanshinone IIA possessed obvious protective effect against liver injury induced by CCl4 or D-GalN. |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
