Sevoflurane low-flow anaesthesia: best strategy to reduce Compound A concentration |
| |
Authors: | Di Filippo A Marini F Pacenti M Dugheri S Focardi L Novelli G P |
| |
Affiliation: | Department of Medical and Surgical Critical Care, University of Florence, Italy. aledanibatibeba@hotmail.com |
| |
Abstract: | BACKGROUND: To define the best strategy to reduce Compound A production in Sevoflurane low-flow anaesthesia by experiments in vitro and in vivo of different absorbers and different anaesthesia machines. METHODS: In vitro Compound A has been measured at 45 degrees C in vitro following Sevoflurane interactions with potassium hydroxide, sodium hydroxide, soda lime, Dragersorb 800 Plus and Amsorb, a new absorber that does not contain sodium or potassium hydroxide. In vivo Compound A concentration in the anaesthesia circuit (inspiratory branch) has been measured using an indirect sampling method through absorber vials (SKC) with active coal granules, during low flows (500 ml/min) general anaesthesia using soda lime, Dragersorb 800 Plus or Amsorb as absorber. Compound A was also measured during low flows (500 ml/min) general anaesthesia using as carbon dioxide absorber soda lime with different anaesthesia machines. RESULTS: In vitro at 45 degrees C Compound A concentration with soda lime and Dragersorb 800 Plus was about 10 times higher than with Amsorb. In vivo the Compound A concentrations in the inspiratory branch of the circuit were lower in the group with Amsorb. CONCLUSION: The Compound A production is minimal with Amsorb as carbon dioxide absorber. |
| |
Keywords: | Anesthesia machine Compound A low-flow anesthesia Sevoflurane |
本文献已被 PubMed 等数据库收录! |
|