Macrophages release tumor necrosis factor alpha and interleukin-12 in response to intracellular Bacillus anthracis spores |
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| Authors: | Pickering Alison K Merkel Tod J |
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| Affiliation: | Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. |
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| Abstract: | Herein we report that infection of a murine macrophage cell line with Bacillus anthracis results in the production of tumor necrosis factor alpha and interleukin-12 (IL-12). When infected with B. anthracis spores in combination with lipopolysaccharide, macrophages release increased amounts of IL-12. We found no evidence of inhibition of cytokine responses in macrophages infected with B. anthracis spores. |
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