Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings |
| |
| Authors: | Heleen B.M. Boos René C.W. Mandl Neeltje E.M. van Haren Wiepke Cahn G. Caroline M. van Baal René S. Kahn Hilleke E. Hulshoff Pol |
| |
| Affiliation: | 1. Clinical Neuroscience of Schizophrenia (CNS) Laboratory, Department of Psychology, Hotchkiss Brain Institute, University of Calgary, 2500 University Drive, NW Calgary, AB T2N 1N4, Canada;2. Translational MRI, Department of Imaging and Pathology, KU Leuven and Radiology, University Hospitals Leuven, Belgium;1. Department of Neuropsychiatry, Toho University School of Medicine, Tokyo, Japan;2. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Melbourne, Australia;3. Melbourne School of Engineering, The University of Melbourne, Melbourne, Australia;4. Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan;5. Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan;6. Department of Social Medicine, Toho University School of Medicine, Tokyo, Japan;7. Department of Radiology, Toho University School of Medicine, Tokyo, Japan;1. Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA;2. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA;1. Psychiatry Neuroimaging Laboratory, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA, USA;2. VA Boston Healthcare System, Brockton, MA, United States;3. Harvard Medical School, Boston, MA, USA;4. Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA;5. Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA;6. Massachusetts Mental Health Center, Division of Public Psychiatry, Boston, MA, USA;1. Dokuz Eylul University, Faculty of Medicine, Department of Psychiatry, Izmir, Turkey;2. McLean Hospital, 115 Mill St., Belmont, MA 02478, USA;3. Harvard Medical School, Department of Psychiatry, Boston, MA 02114, USA;1. Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, 34 Kashirskoe shosse, 115522 Moscow, Russia;2. Department of Radiology, Children''s Clinical and Research Institute of Emergency Surgery and Trauma, Moscow, Russia;3. Department of Endogenous Mental Disorders, Mental Health Research Center, Moscow, Russia |
| |
| Abstract: | ![]()
Structural brain abnormalities have consistently been found in patients with schizophrenia. Diffusion tensor imaging (DTI) has been shown to be a useful method to measure white matter (WM) integrity in this illness, but findings in the earlier disease stages are inconclusive. Moreover, the relationship between WM microstructure and the familial risk for developing schizophrenia remains unresolved. From 126 patients with schizophrenia, 123 of their non-psychotic siblings and 109 healthy control subjects, DTI images were acquired on a 1.5 T MRI scanner. Mean fractional anisotropy (FA) was compared along averaged WM tracts, computed for the genu, splenium, left and right uncinate fasciculus, cingulum, inferior fronto-occipital fasciculus, fornix, arcuate fasciculus, and inferior longitudinal fasciculus. Fractional anisotropy (FA) was assessed for its unique environmental and familial (possibly heritable) aspects associated with schizophrenia, using structural equation modeling for these white matter tracts. The results of this study show that young adult (mean age 26.7 years) patients with schizophrenia did not differ in mean FA from healthy controls along WM fibers; siblings of patients showed higher mean FA in the left and right arcuate fasciculus as compared to patients and controls. With increasing age, an excessive decline in mean FA was found in patients as compared to siblings and healthy controls in the genu, left uncinate fasciculus, left inferior fronto-occipital fasciculus, and left inferior longitudinal fasciculus. Moreover, symptom severity was negatively correlated to mean FA in the arcuate fasciculus bilaterally in patients with schizophrenia. In young adult patients with schizophrenia integrity of individual tract-based (corticocortical) fibers can (still) be within normal limits. However, changes in the arcuate fasciculus may be relevant to (the risk to develop) psychosis, while a general and widespread loss of fiber integrity may be related to illness progression. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
