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Phase I/II trial of combination therapy with S-1 and weekly paclitaxel in patients with unresectable or recurrent gastric cancer
Authors:Seisuke Inada  Takashi Tomidokoro  Hiroyuki Fukunari  Tomomi Sato  Toru Hatano  Atsushi Nishimura  Yasuyuki Kawauchi  Keiya Nikkuni  Takeaki Shimizu  Toshiteru Sato  Masahiko Yanagi  Satoru Takahashi  Hideki Yoshida  Minoru Sugita  Tetsuji Hayashi
Affiliation:Inada Clinic, 1-6-23-10 Kasuga, Kashiwazaki, Niigata 945-0074, Japan. inadaclinic@snow.plala.or.jp
Abstract:Purpose  We aimed to examine the safety and antitumor effects of a combination of S-1 and paclitaxel in patients with unresectable or recurrent gastric cancer in a phase I/II setting. Patients and methods  The study was designed as a phase I/II clinical trial. In phase I portion, the dose of paclitaxel was escalated to estimate the maximum-tolerated dose (MTD) and recommended dose (RD) of paclitaxel with fixed dose of S-1. S-1 (daily dose, 80 mg/m2) was given orally on days 1–21 every 35-day cycle (rest on days 22–35). Paclitaxel was administered intravenously on days 1, 8 and 15, at an initial dose of 40 mg/m2, stepping up to 70 mg/m2 in 10-mg/m2 increment. Dose-limiting toxicity (DLT) was defined as grade 4 hematological toxicity, grade 3 or higher nonhematological toxicity, and treatment discontinuation due to adverse reactions during the first course of treatment. In phase II portion, the efficacy and toxicity at the RD of paclitaxel with S-1 were assessed. Results  The MTD of paclitaxel was estimated to be 60 mg/m2, because >33.3% of patients (2/3) developed DLTs. DLT included postponement of treatment due to grade 2 neutropenia, and grade 3 stomatitis, anorexia, and nausea. Therefore, the RD of paclitaxel was estimated to be 50 mg/m2. In the phase II portion, 22 patients were evaluated with 50 mg/m2 paclitaxel and 80 mg/m2 S-1 in a 35-day cycle. The response rate was 54.5% (95% CI, 32.2–75.6%). The median survival time was 283 days (95% CI, 218–508 days). The median number of treatment courses was 4 (range 1–10), indicating that this regimen could be given repeatedly. Conclusions  This phase I/II trial of combination therapy with S-1 and paclitaxel in patients with unresectable or recurrent gastric cancer showed that this regimen has substantial antitumor activity and can be given safely.
Keywords:S-1  Paclitaxel  Advanced gastric cancer  Phase I/II
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