| JUNB基因和TOB1基因在肝细胞癌中的表达及意义 |
| |
| 引用本文： | 张彧,陈铃,何国珍,邓伟,张春燕,黄天壬. JUNB基因和TOB1基因在肝细胞癌中的表达及意义[J]. 陕西肿瘤医学, 2013, 0(11): 2504-2507 |
| |
| 作者姓名： | 张彧 陈铃 何国珍 邓伟 张春燕 黄天壬 |
| |
| 作者单位： | [1]广西医科大学附属肿瘤医院,广西南宁530021 [2]广西壮族自治区肿瘤防治研究所,广西南宁530021 [3]广西中医学院,广西南宁530222 |
| |
| 基金项目： | 国家自然科学基金项目（编号：30960333）;广西自然科学基金资助项目（编号：桂科自0991017Z） |
| |
| 摘 要： | 目的：探讨JUNB基因和TOB1基因的表达在原发性肝细胞癌（HCC）发生发展中的作用.方法：应用半定量逆转录聚合酶链（RT-PCR）技术检测55例肝癌患者、55例其它肿瘤患者和33例对照组患者外周血JUNB基因和TOB1基因的表达.结果：各组间外周血JUNB基因和TOB1基因阳性表达率无差异,JUNB基因和TOB1基因在肝癌患者外周血中的表达水平明显高于其他组（分别为P=0.003和P=0.000）,其他组之间无差异.结论：JUNB基因和TOB1基因在外周血中的mRNA表达水平可能与肝癌发生密切相关,提示其表达水平可能与预测HCC发生、发展有明显相关性.
|
| 关 键 词： | 基因 JUNB TOB1 原发性肝细胞癌 RT-PCR |
JUNB and TOB1 gene expression and significance in hepatocellular carcinoma |
| |
| Zhang Yu,Chen Ling,He Guozhen,Deng Wei,Zhang Chunyan,Huang Tianren. JUNB and TOB1 gene expression and significance in hepatocellular carcinoma[J]. Shaanxi Oncology Medicine, 2013, 0(11): 2504-2507 |
| |
| Authors: | Zhang Yu Chen Ling He Guozhen Deng Wei Zhang Chunyan Huang Tianren |
| |
| Affiliation: | 1.The Affiliated Tumor Hospital of Guangxi Medical University, Guangxi Nanning 530021, China; 2.Guangxi Cancer Institute, Guangxi Nanning 530021, China; 3.College of Traditional Chinese Medicine of Guangxi, Guangxi Nanning 530222, China;) |
| |
| Abstract: | Objective：To explore the role of JUNB genes and TOB1 gene expression in the development of hepatocellular carcinoma（HCC）.Methods：By using semi-quantitative reverse transcriptase PCR（RT-PCR） technology to detect 55 cases of liver cancer.55 patients with other tumor and 33 control for JUNB gene and TOB1 gene expression.Results：The comparison between peripheral blood JUNB and TOB1 gene expression was no difference,the expression level of JUNB gene and TOB1 gene in peripheral blood of patients with hepatocellular carcinoma were significantly higher than that in other groups（P =0.003 and P =0.000）,in the other group there was no difference.Conclusion：The level of expression of mRNA JUNB gene and TOB1 gene in the peripheral blood is associated with HCC,occurrence,development. |
| |
| Keywords: | gene JUNB TOB1 hepatocellular carcinoma RT-PCR |
| 本文献已被 维普 等数据库收录！ |
|
